Surface-Enhanced Raman Spectroscopy for Biomedical Applications: Recent Advances and Future Challenges

Authors: Li Lin, Ramón A. Álvarez‐Puebla, Luis M. Liz‐Marzán, Matt Trau, Jing Wang, Laura Fabris, Xiang Wang, Guokun Liu, Shuping Xu, Xiao Han, Liangbao Yang, Aiguo Shen, Shikuan Yang, Yikai Xu, Chunchun Li, Jinqing Huang, Shao-Chuang Liu, Jian‐An Huang, Indrajit Srivastava, Ming Li, Limei Tian, Lam Bang Thanh Nguyen, Xinyuan Bi, Dana Cialla‐May, Pavel Matousek, Nicholas Stone, Randy P. Carney, Wei Ji, Wei Song, Zhou Chen, In Yee Phang, Malou Henriksen‐Lacey, Hao Chen, Zongyu Wu, Heng Guo, Hao Ma, Gennadii Ustinov, Si-Heng Luo, Sara Mosca, Benjamin Gardner, Yi‐Tao Long, Jürgen Popp, Bin Ren, Shuming Nie, Bing Zhao, Xing Yi Ling, Jian Ye - ACS Applied Materials & Interfaces 2025 cited by 193

deep Raman spectroscopy, emphasizing its potential for liquid biopsy, metabolic phenotyping, and extracellular vesicle diagnostics. The review concludes with a perspective on clinical translation of SERS, addressing commercialization potentials and the challenges in deep tissue in vivo sensing and imaging.