NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis

Authors: Samantha Alvarez, Vladislav O. Sviderskiy, Erdem M. Terzi, Thales Papagiannakopoulos, André L. Moreira, Sylvia Adams, Kıvanç Birsoy, David M. Sabatini, Richard Possemato - Nature 2017 cited by 821

Cancers growing in high-oxygen environments, such as lung adenocarcinomas, select for the iron–sulfur cluster synthesizing enzyme NFS1 to support malignant proliferation and to protect from oxidative damage.