Predicting Neurodegenerative Disease Using Prepathology Gut Microbiota Composition: a Longitudinal Study in Mice Modeling Alzheimer’s Disease Pathologies

Authors: Emily M. Borsom, Kathryn A Conn, Christopher R. Keefe, Chloe Herman, Gabrielle M Orsini, Allyson H. Hirsch, Melanie Palma Avila, George Testo, Sierra A. Jaramillo, Evan Bolyen, Keehoon Lee, J. Gregory Caporaso, Emily K. Cope - Microbiology Spectrum 2023 cited by 45

Recent studies have demonstrated alterations in the gut microbiota composition in mice modeling Alzheimer’s disease (AD) pathologies; however, these studies have only included up to 4 time points. Our study is the first of its kind to characterize the gut microbiota of a transgenic AD mouse model, fortnightly, from 4 weeks of age to 52 weeks of age, to quantify the temporal dynamics in the microbial composition that correlate with the development of disease pathologies and host immune gene expression.