5-Aminosalicylic Acid Ameliorates Colitis and Checks Dysbiotic Escherichia coli Expansion by Activating PPAR-γ Signaling in the Intestinal Epithelium

Authors: Stephanie A. Cevallos, Jee‐Yon Lee, Eric M. Velazquez, Nora J. Foegeding, Catherine Shelton, Connor R. Tiffany, Beau H. Parry, Annica R. Stull-Lane, Erin E. Olsan, Hannah P. Savage, Henry Nguyen, Star S. Ghanaat, Austin J. Byndloss, Ilechukwu Agu, Renée M. Tsolis, Mariana X. Byndloss, Andreas J. Bäumler - mBio 2021 cited by 132

An expansion of Enterobacterales in the fecal microbiota is a microbial signature of dysbiosis that is linked to many noncommunicable diseases, including ulcerative colitis. Here, we used Escherichia coli , a representative of the Enterobacterales , to show that its dysbiotic expansion during colitis can be remediated by modulating host epithelial metabolism.