Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis

Authors: Lukáš Bajer, Miloslav Kverka, Martin Kostovčík, Peter Mačinga, Jiří Dvořák, Zuzana Stehlíková, Jan Březina, Pavel Wohl, Julius Špičák, Pavel Drastich - World Journal of Gastroenterology 2017 cited by 380

AIM: To characterize the gut bacterial microbiota of patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). METHODS: = 11) concomitant inflammatory bowel disease, 32 UC patients, and 31 healthy controls. The V3 and V4 regions of the 16S ribosomal RNA gene were sequenced on Illumina MiSeq platform to cover low taxonomic levels. Data were further processed in QIIME employing MaAsLin and LEfSe tools for analysis of the output data. RESULTS: . Low levels of serum albumin were significantly correlated with enrichment of order Actinomycetales. CONCLUSION: PSC is associated with specific gut microbes independently of concomitant IBD and several bacterial taxa clearly distinguish IBD phenotypes (PSC-IBD and UC).