Empty virions in AAV8 vector preparations reduce transduction efficiency and may cause total viral particle dose-limiting side effects

Authors: Kai Gao, Mengxin Li, Zhong‐Guang Li, Qin Su, Jia Li, Shaoyong Li, Ran He, Yu Zhang, Gregory Hendricks, Junzhi Wang, Guangping Gao - Molecular Therapy — Methods & Clinical Development 2014 cited by 165

transduction. Our results suggest that removal of empty particles from rAAV preparations may improve efficacy and safety of AAV in clinical applications.