Extracellular vesicles deposit PCNA to rejuvenate aged bone marrow–derived mesenchymal stem cells and slow age-related degeneration

Authors: Qian Lei, Fei Gao, Teng Liu, Wenxiang Ren, Li Chen, Yulin Cao, Wenlan Chen, Shaojun Guo, Qiong Zhang, Weiqun Chen, Hongxiang Wang, Zhichao Chen, Qiubai Li, Yu Hu, An‐Yuan Guo - Science Translational Medicine 2021 cited by 165

) into recipient AB-MSCs. When tested in therapeutic context, UC-EV-triggered rejuvenation enhanced the regenerative capacities of AB-MSCs in bone formation, wound healing, and angiogenesis. Intravenously injected UC-EVs conferred anti-aging phenotypes including decreased bone and kidney degeneration in aged mice. Our findings reveal that UC-EVs are of high translational value in anti-aging intervention.