Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium

Authors: Xiangzhen Kong, Samuel R. Mathias, Tulio Guadalupe, ENIGMA Laterality Working Group, David C. Glahn, Barbara Franke, Fabrice Crivello, Nathalie Tzourio-Mazoyer, Simon E. Fisher, Paul M. Thompson, Clyde Francks, ENIGMA Laterality Working Group, Xiangzhen Kong, Samuel R. Mathias, Tulio Guadalupe, Christoph Abé, Ingrid Agartz, Theophilus N. Akudjedu, André Alemán, Saud Alhusaini, Nicholas B. Allen, David Ames, Ole A. Andreassen, Alejandro Arias Vásquez, Nicola J. Armstrong, Felipe P. G. Bergo, Mark E. Bastin, Albert Batalla, Jochen Bauer, Bernhard T. Baune, Ramona Baur‐Streubel, Joseph Biederman, Sara K. Blaine, Premika S.W. Boedhoe, Erlend Bøen, Anushree Bose, Janita Bralten, Daniel Brandeis, Silvia Brem, Henry Brodaty, Dilara Yüksel, Samantha J. Brooks, Jan Buitelaar, Christian Bürger, Robin Bülow, Vince D. Calhoun, Anna Calvo, Erick J. Canales‐Rodríguez, José M. Cañive, Dara M. Cannon, Elisabeth C. Caparelli, F. Xavier Castellanos, Gianpiero L. Cavalleri, Fernando Cendes, Tiffany Chaim-Avancini, Kaylita Chantiluke, Qunlin Chen, Xiayu Chen, Yuqi Cheng, Anastasia Christakou, Vincent P. Clark, David Coghill, Colm G. Connolly, Annette Conzelmann, Aldo Córdova‐Palomera, Janna Cousijn, Tim Crow, Ana Cubillo, Anders M. Dale, Udo Dannlowski, Sara Ambrosino de Bruttopilo, Patrick de Zeeuw, Ian J. Deary, Norman Delanty, Damion V. Demeter, Adriana Di Martino, Erin W. Dickie, Bruno Dietsche, Nhat Trung Doan, Colin P. Doherty, Alysa E. Doyle, Sarah Durston, Eric Earl, Stefan Ehrlich, Carl Johan Ekman, Torbjørn Elvsåshagen, Jeffery N. Epstein, Damien A. Fair, Stephen V. Faraone, Guillén Fernández, Geraldo F. Busatto, Katharina Förster, Jean‐Paul Fouché, John J. Foxe, Thomas Frodl, Paola Fuentes‐Claramonte, Janice M. Fullerton, Hugh Garavan, Danielle do Santos Garcia, Ian H. Gotlib, Anna E. Goudriaan, Hans J. Grabe, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Tiril P. Gurholt, Jan Haavik, Tim Hahn, Narelle K. Hansell, Mathew A. Harris, Catharina A. Hartman, María Valdés Hernández, Dirk J. Heslenfeld, Robert Hester, Derrek P. Hibar, Beng‐Choon Ho, Tiffany C. Ho, Pieter J. Hoekstra, Ruth J. van Holst, Martine Hoogman, Marie F. Høvik, Fleur M. Howells, Kenneth Hugdahl, Chaim Huyser, Martin Ingvar, Lourdes Irwin, Akari Ishikawa, Anthony James, Neda Jahanshad, Terry L. Jernigan, Erik G. Jönsson, Claas Kähler, В. Г. Каледа, Clare Kelly, Michael Kerich, Matcheri S. Keshavan, Sabin Khadka, Tilo Kircher, Gregor Kohls, Kerstin Konrad, Ozlem Korucuoglu, Bernd Krämer, Axel Krug, Jun Soo Kwon, Nanda Lambregts-Rommelse, Mikael Landén, Luisa Lázaro, И. С. Лебедева, Rhoshel Lenroot, Klaus‐Peter Lesch, Qinqin Li, Kelvin O. Lim, Jia Liu, Christine Löchner, Edythe D. London, Vera Lonning, Valentina Lorenzetti, Michelle Luciano, Maartje Luijten, Astri J. Lundervold, Scott Mackey, Frank P. MacMaster, Sophie Maingault, Charles B. Malpas, Ulrik Fredrik Malt, David Mataix‐Cols, Rocío Martín‐Santos, Andrew R. Mayer, Hazel McCarthy, Philip B. Mitchell, Bryon A. Mueller, Susana Muñoz Maniega, Bernard Mazoyer, Colm McDonald, Quinn McLellan, Katie L. McMahon, Genevieve McPhilemy, Reza Momenan, Angelica M. Morales, Janardhanan C. Narayanaswamy, José Carlos Vasques Moreira, Stener Nerland, Liam J. Nestor, Erik Newman, Joel T. Nigg, Jan Egil Nordvik, Stephanie Novotny, Eileen Oberwelland Weiß, Ruth Tuura, Jaap Oosterlaan, Bob Oranje, Catherine Orr, Bronwyn J. Overs, Paul Pauli, Martin P. Paulus, Kerstin Jessica Plessen, Georg G. von Polier, Edith Pomarol‐Clotet, Marı́a J. Portella, Jiang Qiu, Joaquim Raduà, Josep Antoni Ramos‐Quiroga, Y.C. Janardhan Reddy, Andreas Reif, Gloria Roberts, Pedro G. P. Rosa, Katya Rubia, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Lianne Schmaal, Martin Schulte‐Rüther, Lizanne Schweren, Larry J. Seidman, Jochen Seitz, Maurício H. Serpa, Philip Shaw, Elena Shumskaya, Timothy J. Silk, Alan N. Simmons, Egle Simulionyte, Rajita Sinha, Zsuzsika Sjoerds, Runar Elle Smelror, Joan Carlos Soliva, Nadia Solowij, Fábio Duran, Scott R. Sponheim, Dan J. Stein, Elliot A. Stein, Michael C. Stevens, Lachlan T. Strike, Gustavo Sudre, Jing Sui （Beijing Normal University）， my correct affiliation is beijing normal university, not Qingdao University of Science and Technology, please correct the current affiliation. Thank you, Leanne Tamm, Hendrik S. Temmingh, Robert J. Thoma, A. S. Tomyshev, Giulia Tronchin, Jessica A. Turner, Anne Uhlmann, Theo G.M. van Erp, Odile A. van den Heuvel, Dennis van der Meer, Liza van Eijk, Alasdair Vance, Ilya M. Veer, Dick J. Veltman, Ganesan Venkatasubramanian, Óscar Vilarroya, Yolanda Vives‐Gilabert, Aristotle N. Voineskos, Henry Völzke, Daniella Vuletic, Susanne Walitza, Henrik Walter, Esther Walton, Joanna M. Wardlaw, Wei Wen, Lars T. Westlye, Christopher D. Whelan, Tonya White, Reínout W. Wiers, Margaret J. Wright, Katharina Wittfeld, Tony T. Yang, Clarissa Lin Yasuda, Yuliya Yoncheva, Murat Yücel, Je‐Yeon Yun, Marcus V. Zanetti, Zonglei Zhen, Xingxing Zhu, Georg Ziegler, Kathrin C. Zierhut, Greig I. de Zubicaray, Marcel P. Zwiers, Karolinska Schizophrenia Project (KaSP), David C. Glahn, Barbara Franke, Fabrice Crivello, Nathalie Tzourio-Mazoyer, Simon E. Fisher, Paul M. Thompson, Clyde Francks, Lars Farde, Lena Flyckt, Göran Engberg, Sophie Erhardt, Helena Fatouros‐Bergman, Simon Červenka, Lilly Schwieler, Fredrik Piehl, Ingrid Agartz, Karin Collste, Pauliina Victorsson, Anna Malmqvist, Mikael Hedberg, Funda Orhan - Proceedings of the National Academy of Sciences, PNAS 2018 cited by 459

Significance Left–right asymmetry is a key feature of the human brain's structure and function. It remains unclear which cortical regions are asymmetrical on average in the population and how biological factors such as age, sex, and genetic variation affect these asymmetries. Here, we describe by far the largest-ever study of cerebral cortical asymmetry, based on data from 17,141 participants. We found a global anterior–posterior “torque” pattern in cortical thickness, together with various regional asymmetries at the population level, which have not been previously described, as well as effects of age, sex, and heritability estimates. From these data, we have created an online resource that will serve future studies of human brain anatomy in health and disease.