EZH2 activates CHK1 signaling to promote ovarian cancer chemoresistance by maintaining the properties of cancer stem cells

Authors: Yiping Wen, Yaya Hou, Xiaoqing Yi, Si Sun, Jing Guo, Xiaoqi He, Tao Li, Jing Cai, Zehua Wang - Theranostics 2020 cited by 100

Our data revealed a previously unidentified functional and mechanistic link between EZH2 levels, CHK1 signaling activation, and ovarian CSCs and provided strong evidence that EZH2 promotes ovarian cancer chemoresistance and recurrence.