A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility

Authors: Shu‐Hsien Sheu, Srigokul Upadhyayula, Vincent Dupuy, Song Pang, Fei Deng, Jinxia Wan, Deepika Walpita, H. Amalia Pasolli, Justin R. Houser, Silvia Sánchez-Martínez, Sebastián Brauchi, Sambashiva Banala, Melanie Freeman, C. Shan Xu, Tomas Kirchhausen, Harald F. Hess, Luke D. Lavis, Yulong Li, Séverine Chaumont‐Dubel, David E. Clapham - Cell 2022 cited by 175

-RhoA pathway, which modulates nuclear actin and increases histone acetylation and chromatin accessibility. Ablation of this pathway reduces chromatin accessibility in CA1 pyramidal neurons. As a signaling apparatus with proximity to the nucleus, axo-ciliary synapses short circuit neurotransmission to alter the postsynaptic neuron's epigenetic state.