Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma

Authors: Brian A. Walker, Konstantinos Mavrommatis, Christopher P. Wardell, Cody Ashby, Michael Bauer, Faith E. Davies, Adam Rosenthal, Hongwei Wang, Pingping Qu, Antje Hoering, Mehmet Samur, Fadi Towfic, María Ortiz, Erin Flynt, Zhinuan Yu, Zhihong Yang, Dan Rozelle, John C. Obenauer, Matthew Trotter, Daniel Auclair, Jonathan J. Keats, Niccolò Bolli, Mariateresa Fulciniti, Raphaël Szalat, Philippe Moreau, Brian G.M. Durie, A. Keith Stewart, Hartmut Goldschmidt, Marc S. Raab, Hermann Einsele, Pieter Sonneveld, Jesús F. San Miguel, Sagar Lonial, Graham Jackson, Kenneth C. Anderson, Hervé Avet‐Loiseau, Nikhil Munshi, Anjan Thakurta, Gareth J. Morgan - Blood 2018 cited by 495

rearrangements. These associations indicate that the genomic landscape of myeloma is predetermined by the primary events upon which further dependencies are built, giving rise to a nonrandom accumulation of genetic hits. Understanding these dependencies may elucidate potential evolutionary patterns and lead to better treatment regimens.