APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer’s Disease

Authors: Yakeel T. Quiroz, David Aguillón, Daniel Camilo Aguirre–Acevedo, Daniel Vásquez, Yesica Zuluaga, Ana Baena, Lucía Madrigal, Liliana Hincapié, Justin S. Sanchez, Stephanie Langella, Rafael Posada‐Duque, Jessica Lisa Littau, Nelson David Villalba‐Moreno, Clara Vila‐Castelar, Liliana Ramírez Gómez, Gloria García, Elizabeth Kaplan, Susana Vargas, J. Alejandro Ossa, Pablo Valderrama‐Carmona, Paula Perez‐Corredor, Susanne Krasemann, Markus Glatzel, Kenneth S. Kosik, Keith Johnson, Reisa A. Sperling, Eric M. Reiman, Diego Sepúlveda‐Falla, Francisco Lopera, Joseph F. Arboleda‐Velásquez - New England Journal of Medicine, NEJM 2024 cited by 57

BACKGROUND: variant is prevalent. METHODS: variant. Two participants underwent brain imaging, and autopsy was performed in four participants. RESULTS: variant. CONCLUSIONS: variant in a kindred with a high prevalence of autosomal dominant Alzheimer's disease. (Funded by Good Ventures and others.).