An in vivo atlas of host–pathogen transcriptomes during Streptococcus pneumoniae colonization and disease

Authors: Adonis D’Mello, Ashleigh N. Riegler, Eriel Martínez, Sarah M. Beno, Tiffany D. Ricketts, Ellen F. Foxman, Carlos J. Orihuela, Hervé Tettelin - Proceedings of the National Academy of Sciences, PNAS 2020 cited by 66

Significance We detail host–pathogen interaction gene-expression profiles of Streptococcus pneumoniae ( Spn ) and its infected host at disease relevant anatomical sites using mice as experimental models. We identify the shared and organ-specific transcriptomes of Spn , show that bacterial and host gene-expression profiles are highly distinct during asymptomatic colonization versus disease-causing infection, and demonstrate that Spn and host genes with high levels of expression contribute to pathogenesis or host defense, respectively, making them optimal targets for intervention.