Targeting Interleukin-5 in Refractory and Relapsing Churg–Strauss Syndrome
Letters6 September 2011Targeting Interleukin-5 in Refractory and Relapsing Churg–Strauss SyndromeFrank Moosig, MD, PhD, Wolfgang Ludwig Gross, MD, PhD, Kristina Herrmann, MD, Jan Phillip Bremer, MD, and Bernhard Hellmich, MD, PhDFrank Moosig, MD, PhDFrom University of Lübeck and Clinic Bad Bramstedt, 24576 Bad Bramstedt, Germany, and University of Tübingen and Hospital Plochingen, 73207 Tübingen, Germany., Wolfgang Ludwig Gross, MD, PhDFrom University of Lübeck and Clinic Bad Bramstedt, 24576 Bad Bramstedt, Germany, and University of Tübingen and Hospital Plochingen, 73207 Tübingen, Germany., Kristina Herrmann, MDFrom University of Lübeck and Clinic Bad Bramstedt, 24576 Bad Bramstedt, Germany, and University of Tübingen and Hospital Plochingen, 73207 Tübingen, Germany., Jan Phillip Bremer, MDFrom University of Lübeck and Clinic Bad Bramstedt, 24576 Bad Bramstedt, Germany, and University of Tübingen and Hospital Plochingen, 73207 Tübingen, Germany., and Bernhard Hellmich, MD, PhDFrom University of Lübeck and Clinic Bad Bramstedt, 24576 Bad Bramstedt, Germany, and University of Tübingen and Hospital Plochingen, 73207 Tübingen, Germany.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-155-5-201109060-00026 SectionsSupplemental MaterialAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This article has been corrected. The original version (PDF) is appended to this article as a supplement.Background: Hypereosinophilia plays a critical role in the pathogenesis of the Churg–Strauss syndrome. Interleukin-5 (IL-5) is the most potent inducer of maturation and activation of eosinophils. We demonstrated elsewhere (1) that IL-5 production is increased in the Churg–Strauss syndrome and that interferon-α therapy, which downregulates IL-5 production, can induce remission of this condition (2). However, long-term results with interferon-α and other biological and conventional drugs, such as cyclophosphamide, have been disappointing.Frequent relapses, the need for long-term medium- to high-dose glucocorticosteroid therapy, and ...References1. Hellmich B, Csernok E, Gross WL. Proinflammatory cytokines and autoimmunity in Churg-Strauss syndrome. Ann N Y Acad Sci. 2005;1051:121-31. [PMID: 16126951] CrossrefMedlineGoogle Scholar2. Tatsis E, Schnabel A, Gross WL. Interferon-alpha treatment of four patients with the Churg-Strauss syndrome. Ann Intern Med. 1998;129:370-4. [PMID: 9735064] LinkGoogle Scholar3. Rothenberg ME, Klion AD, Roufosse FE, Kahn JE, Weller PF, Simon HU, et al; Mepolizumab HES Study Group. Treatment of patients with the hypereosinophilic syndrome with mepolizumab. N Engl J Med. 2008;358:1215-28. [PMID: 18344568] CrossrefMedlineGoogle Scholar4. Kim S, Marigowda G, Oren E, Israel E, Wechsler ME. Mepolizumab as a steroid-sparing treatment option in patients with Churg-Strauss syndrome. J Allergy Clin Immunol. 2010;125:1336-43. [PMID: 20513524] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Lübeck and Clinic Bad Bramstedt, 24576 Bad Bramstedt, Germany, and University of Tübingen and Hospital Plochingen, 73207 Tübingen, Germany.Disclosures: This study was financially supported by GSK, and GSK provided the study medication. 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