The chromosomal protein SMCHD1 regulates DNA methylation and the 2c-like state of embryonic stem cells by antagonizing TET proteins

Authors: Zhijun Huang, Jiyoung Yu, Wei Cui, Benjamin K. Johnson, Kyunggon Kim, Gerd P. Pfeifer - Science Advances 2021 cited by 55

, and other genes upon SMCHD1 loss depend on TET proteins. These data identify SMCHD1 as an antagonist of the 2c-like state of ES cells and of TET-mediated DNA demethylation.