A Novel PD-L1-targeting Antagonistic DNA Aptamer With Antitumor Effects

Authors: Wei‐Yun Lai, Bo-Tsang Huang, Jen-Wei Wang, Pei-Ying Lin, Pan‐Chyr Yang - Molecular Therapy — Nucleic Acids 2016 cited by 166

intratumoral microvessels were significantly decreased in the aptPD-L1 treatment group. Collectively, our data suggested that aptPD-L1 helps T cell function restoration and modifies tumor microenvironment. These chemokines might orchestrate together to attract more T cells into the tumor tissues to form the positive amplification loop against tumor growth, indicating the translational potential of aptPD-L1 in cancer immunotherapy.