David C. Linehan

1995–2025 年に発表

85: 論文数
18,559: 被引用数
72: h 指数
84: i10 指数

被引用数

引用元

国・地域

0%30.3%その他 20%

機関

分野

トピック

全論文

並び替え

検索で開く

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models
著者: Yu Zhu, Brett L. Knolhoff, Melissa A. Meyer, Timothy M. Nywening, Brian L. West, Jingqin Luo, Andrea Wang‐Gillam, S. Peter Goedegebuure, David C. Linehan, David G. DeNardo - Cancer Research 2014 被引用: 1,287
Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial
著者: Timothy M. Nywening, Andrea Wang‐Gillam, Dominic E. Sanford, Brian A. Belt, Roheena Z. Panni, Brian Cusworth, Adetunji T. Toriola, Rebecca Nieman, Lori A. Worley, Motoyo Yano, Kathryn J. Fowler, A. Craig Lockhart, Rama Suresh, Benjamin Tan, Kian‐Huat Lim, Ryan C. Fields, Steven M. Strasberg, William G. Hawkins, David G. DeNardo, S. Peter Goedegebuure, David C. Linehan - The Lancet Oncology 2016 被引用: 778
Targeting both tumour-associated CXCR2+ neutrophils and CCR2+ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma
著者: Timothy M. Nywening, Brian A. Belt, Darren R. Cullinan, Roheena Z. Panni, Booyeon J. Han, Dominic E. Sanford, Ryan C Jacobs, Jian Ye, Ankit A. Patel, William E. Gillanders, Ryan C. Fields, David G. DeNardo, William G. Hawkins, Peter S. Goedegebuure, David C. Linehan - Gut 2017 被引用: 481
Immunologic Strategies in Pancreatic Cancer: Making Cold Tumors Hot
著者: Nicholas A. Ullman, Paul R. Burchard, Richard F. Dunne, David C. Linehan - Journal of Clinical Oncology 2022 被引用: 311
Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses
著者: Jonathan B. Mitchem, Donal J. Brennan, Brett L. Knolhoff, Brian A. Belt, Yu Zhu, Dominic E. Sanford, Larisa Belaygorod, Danielle Carpenter, Lynne Collins, David Piwnica‐Worms, Stephen M. Hewitt, Girish Mallya Udupi, William M. Gallagher, Craig D. Wegner, Brian L. West, Andrea Wang‐Gillam, Peter S. Goedegebuure, David C. Linehan, David G. DeNardo - Cancer Research 2012 被引用: 941
Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of metastatic pancreatic ductal adenocarcinoma
著者: Marcus Smith Noel, Eileen M. O’Reilly, Brian M. Wolpin, David P. Ryan, Andrea J. Bullock, Carolyn D. Britten, David C. Linehan, Brian A. Belt, Eric Gamelin, Bishu Ganguly, Donghua Yin, Tenshang Joh, Ira Jacobs, Carrie Turich Taylor, Maeve A. Lowery - Investigational New Drugs 2019 被引用: 182
Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis
著者: Dominic E. Sanford, Brian A. Belt, Roheena Z. Panni, Allese Mayer, Anjali D. Deshpande, Danielle Carpenter, Jonathan B. Mitchem, Stacey M. Plambeck-Suess, Lori A. Worley, Brian D. Goetz, Andrea Wang‐Gillam, Timothy J. Eberlein, David G. DeNardo, S. Peter Goedegebuure, David C. Linehan - Clinical Cancer Research 2013 被引用: 613
Purity Independent Subtyping of Tumors (PurIST), A Clinically Robust, Single-sample Classifier for Tumor Subtyping in Pancreatic Cancer
著者: Naim U. Rashid, Xianlu L. Peng, Chong Jin, Richard A. Moffitt, Keith E. Volmar, Brian A. Belt, Roheena Z. Panni, Timothy M. Nywening, Silvia G. Herrera, Kristin J. Moore, Sarah G. Hennessey, Ashley B. Morrison, Ryan Kawalerski, Apoorve Nayyar, Audrey E. Chang, Benjamin Schmidt, Han Jo Kim, David C. Linehan, Jen Jen Yeh - Clinical Cancer Research 2019 被引用: 238
Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity
著者: Hannah L. Williams, Andressa Dias Costa, Jinming Zhang, Srivatsan Raghavan, Peter Winter, Kevin S. Kapner, Scott P. Ginebaugh, Sara A. Väyrynen, Juha P. Väyrynen, Chen Yuan, Andrew W. Navia, Junning Wang, Annan Yang, Timothy L. Bosse, Radha L. Kalekar, Kristen E. Lowder, Mai Chan Lau, Dalia Elganainy, Vicente Morales-Oyarvide, Douglas A. Rubinson, Harshabad Singh, Kimberly Perez, James M. Cleary, Thomas E. Clancy, Jiping Wang, Joseph D. Mancias, Lauren K. Brais, Emma R. Hill, Margaret M. Kozak, David C. Linehan, Richard F. Dunne, Daniel T. Chang, Albert C. Koong, Aram F. Hezel, William C. Hahn, Alex K. Shalek, Andrew J. Aguirre, Jonathan A. Nowak, Brian M. Wolpin - Cancer Research 2022 被引用: 90
Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients
著者: Mark Sausen, Jillian Phallen, Vilmos Adleff, Siân Jones, Rebecca Leary, Michael T. Barrett, Valsamo Anagnostou, Sonya Parpart-Li, Derek Murphy, Qing Kay Li, Carolyn Hruban, Rob Scharpf, James R. White, Peter J. O’Dwyer, Peter J. Allen, James R. Eshleman, Craig B. Thompson, David S. Klimstra, David C. Linehan, Anirban Maitra, Ralph H. Hruban, Luis A. Díaz, Daniel D. Von Hoff, Julia S. Johansen, Jeffrey A. Drebin, Victor E. Velculescu - Nature Communications 2015 被引用: 484
Disruption of CCR5-Dependent Homing of Regulatory T Cells Inhibits Tumor Growth in a Murine Model of Pancreatic Cancer
著者: Marcus Tan, Peter S. Goedegebuure, Brian A. Belt, Brian Flaherty, Narendra V. Sankpal, William E. Gillanders, Timothy J. Eberlein, Chyi‐Song Hsieh, David C. Linehan - The Journal of Immunology 2009 被引用: 450
Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer
著者: Sara A. Väyrynen, Jinming Zhang, Chen Yuan, Juha P. Väyrynen, Andressa Dias Costa, Hannah L. Williams, Vicente Morales‐Oyarvide, Mai Chan Lau, Douglas A. Rubinson, Richard F. Dunne, Margaret M. Kozak, Wenjia Wang, Diana Agostini‐Vulaj, Michael G. Drage, Lauren K. Brais, Emma Reilly, Osama E. Rahma, Thomas E. Clancy, Jiping Wang, David C. Linehan, Andrew J. Aguirre, Charles S. Fuchs, Lisa M. Coussens, Daniel T. Chang, Albert C. Koong, Aram F. Hezel, Shuji Ogino, Jonathan A. Nowak, Brian M. Wolpin - Clinical Cancer Research 2020 被引用: 159
Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma
著者: Zhi Rong Qian, Douglas A. Rubinson, Jonathan A. Nowak, Vicente Morales‐Oyarvide, Richard F. Dunne, Margaret M. Kozak, Marisa W. Welch, Lauren K. Brais, Annacarolina da Silva, Tingting Li, Wanwan Li, Atsuhiro Masuda, Juhong Yang, Yan Shi, Mancang Gu, Yohei Masugi, Justin Bui, Caitlin L. Zellers, Chen Yuan, Ana Babić, Natalia Khalaf, Andrew J. Aguirre, Kimmie Ng, Rebecca A. Miksad, Andrea J. Bullock, Daniel T. Chang, Jennifer F. Tseng, Thomas E. Clancy, David C. Linehan, Jennifer J. Findeis-Hosey, Leona A. Doyle, Aaron R. Thorner, Matthew D. Ducar, Bruce M. Wollison, Angelica Laing, William C. Hahn, Matthew Meyerson, Charles S. Fuchs, Shuji Ogino, Jason L. Hornick, Aram F. Hezel, Albert C. Koong, Brian M. Wolpin - JAMA Oncology 2017 被引用: 269
Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance
著者: Melissa A. Meyer, John Baer, Brett L. Knolhoff, Timothy M. Nywening, Roheena Z. Panni, Xinming Su, Katherine N. Weilbaecher, William G. Hawkins, X. Cynthia, Ryan C. Fields, David C. Linehan, Grant A. Challen, Roberta Faccio, Rebecca Aft, David G. DeNardo - Nature Communications 2018 被引用: 213
Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer
著者: Jian Ye, Bradley N. Mills, Shuyang Qin, Jesse Garrett-Larsen, Joseph D. Murphy, Taylor P. Uccello, Booyeon J. Han, Tara G Vrooman, Carl J. Johnston, Edith M. Lord, Brian A. Belt, David C. Linehan, Scott A. Gerber - Journal for ImmunoTherapy of Cancer 2022 被引用: 74
Neoadjuvant Chemotherapy Is Associated with Altered Immune Cell Infiltration and an Anti-Tumorigenic Microenvironment in Resected Pancreatic Cancer
著者: Andressa Dias Costa, Sara A. Väyrynen, Akhil Chawla, Jinming Zhang, Juha P. Väyrynen, Mai Chan Lau, Hannah L. Williams, Chen Yuan, Vicente Morales-Oyarvide, Dalia Elganainy, Harshabad Singh, James M. Cleary, Kimberly Perez, Kimmie Ng, William A. Freed-Pastor, Joseph D. Mancias, Stephanie K. Dougan, Jiping Wang, Douglas A. Rubinson, Richard F. Dunne, Margaret M. Kozak, Lauren K. Brais, Emma Reilly, Thomas E. Clancy, David C. Linehan, Daniel T. Chang, Aram F. Hezel, Albert C. Koong, Andrew J. Aguirre, Brian M. Wolpin, Jonathan A. Nowak - Clinical Cancer Research 2022 被引用: 76
Prevalence of Regulatory T Cells Is Increased in Peripheral Blood and Tumor Microenvironment of Patients with Pancreas or Breast Adenocarcinoma
著者: Udaya Liyanage, Todd T. Moore, Hong‐Gu Joo, Yoshiyuki Tanaka, Virginia M. Herrmann, Gerard M. Doherty, Jeffrey A. Drebin, Steven M. Strasberg, Timothy J. Eberlein, Peter S. Goedegebuure, David C. Linehan - The Journal of Immunology 2002 被引用: 1,462
Pretreatment Assessment of Resectable and Borderline Resectable Pancreatic Cancer: Expert Consensus Statement
著者: Mark P. Callery, Kenneth J. Chang, Elliot K. Fishman, Mark S. Talamonti, L. William Traverso, David C. Linehan - Annals of Surgical Oncology 2009 被引用: 898
Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth
著者: Matthew R. Porembka, Jonathan B. Mitchem, Brian A. Belt, Chyi‐Song Hsieh, Hyang-Mi Lee, John M. Herndon, William E. Gillanders, David C. Linehan, Peter S. Goedegebuure - Cancer Immunology Immunotherapy 2012 被引用: 278
Recruitment of CCR2+tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer
著者: Julie Grossman, Timothy M. Nywening, Brian A. Belt, Roheena Z. Panni, Bradley A. Krasnick, David G. DeNardo, William G. Hawkins, S. Peter Goedegebuure, David C. Linehan, Ryan C. Fields - OncoImmunology 2018 被引用: 115
The clonal evolution of metastatic colorectal cancer
著者: Ha X. Dang, Bradley A. Krasnick, Brian S. White, Julie Grossman, Matthew S. Strand, Jin Zhang, Christopher R. Cabanski, Christopher A. Miller, Robert S. Fulton, S. Peter Goedegebuure, Catrina C. Fronick, Malachi Griffith, David E. Larson, Brian D. Goetz, Jason Walker, William G. Hawkins, Steven M. Strasberg, David C. Linehan, Kian‐Huat Lim, A. Craig Lockhart, Elaine R. Mardis, Richard K. Wilson, Timothy J. Ley, Christopher A. Maher, Ryan C. Fields - Science Advances 2020 被引用: 77
GM-CSF drives myelopoiesis, recruitment and polarisation of tumour-associated macrophages in cholangiocarcinoma and systemic blockade facilitates antitumour immunity
著者: Luis I. Ruffolo, Katherine M. Jackson, Peyton C. Kuhlers, Benjamin S. Dale, Nathania M Figueroa Guilliani, Nicholas A. Ullman, Paul R. Burchard, Shuyang Qin, Peter Juviler, Jessica M. Keilson, Ashley B. Morrison, Mary Georger, Rachel Jewell, Laura M. Calvi, Timothy M. Nywening, Michael R. O’Dell, Aram F. Hezel, Luis E. De Las Casas, Gregory B. Lesinski, Jen Jen Yeh, Roberto Hernandez‐Alejandro, Brian A. Belt, David C. Linehan - Gut 2021 被引用: 74
Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy
著者: Bradley N. Mills, Haoming Qiu, Michael G. Drage, Chunmo Chen, Jocelyn S. Mathew, Jesse Garrett-Larsen, Jian Ye, Taylor P. Uccello, Joseph D. Murphy, Brian A. Belt, Edith M. Lord, Alan W. Katz, David C. Linehan, Scott A. Gerber - Clinical Cancer Research 2021 被引用: 68
The Accordion Severity Grading System of Surgical Complications
著者: Steven M. Strasberg, David C. Linehan, William G. Hawkins - Annals of Surgery 2009 被引用: 672