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Ernest Hamel

1972–2024 年に発表

118
論文数
18,571
被引用数
83
h 指数
117
i10 指数

被引用数

Ernest Hamel の年別被引用数1973 年: 被引用 2 件1974 年: 被引用 5 件1975 年: 被引用 3 件1976 年: 被引用 2 件1977 年: 被引用 2 件1978 年: 被引用 3 件1979 年: 被引用 2 件1980 年: 被引用 3 件1981 年: 被引用 4 件1982 年: 被引用 7 件1983 年: 被引用 5 件1984 年: 被引用 4 件1985 年: 被引用 2 件1986 年: 被引用 4 件1987 年: 被引用 5 件1988 年: 被引用 12 件1989 年: 被引用 9 件1990 年: 被引用 14 件1991 年: 被引用 19 件1992 年: 被引用 13 件1993 年: 被引用 26 件1994 年: 被引用 15 件1995 年: 被引用 21 件1996 年: 被引用 53 件1997 年: 被引用 73 件1998 年: 被引用 109 件1999 年: 被引用 93 件2000 年: 被引用 133 件2001 年: 被引用 121 件2002 年: 被引用 138 件2003 年: 被引用 182 件2004 年: 被引用 168 件2005 年: 被引用 132 件2006 年: 被引用 157 件2007 年: 被引用 143 件2008 年: 被引用 163 件2009 年: 被引用 126 件2010 年: 被引用 115 件2011 年: 被引用 180 件2012 年: 被引用 120 件2013 年: 被引用 109 件2014 年: 被引用 131 件2015 年: 被引用 100 件2016 年: 被引用 80 件2017 年: 被引用 109 件2018 年: 被引用 44 件2019 年: 被引用 298 件2020 年: 被引用 261 件2021 年: 被引用 231 件2022 年: 被引用 157 件2023 年: 被引用 141 件2024 年: 被引用 195 件2025 年: 被引用 65 件2026 年: 被引用 1 件

引用元

国・地域

この著者を引用した国・地域の世界地図アメリカ合衆国: 引用元論文 1,000 件、この内訳の 29.2%中国: 引用元論文 343 件、この内訳の 10%インド: 引用元論文 257 件、この内訳の 7.5%イギリス: 引用元論文 177 件、この内訳の 5.1%ドイツ: 引用元論文 143 件、この内訳の 4.2%イタリア: 引用元論文 142 件、この内訳の 4.1%フランス: 引用元論文 120 件、この内訳の 3.5%日本: 引用元論文 103 件、この内訳の 3%スペイン: 引用元論文 78 件、この内訳の 2.3%カナダ: 引用元論文 66 件、この内訳の 1.9%エジプト: 引用元論文 65 件、この内訳の 1.9%サウジアラビア: 引用元論文 64 件、この内訳の 1.9%
0%29.2%その他 25.4%

機関

分野

  • Biochemistry, Genetics and Molecular Biology37.1%
  • Medicine26.4%
  • Chemistry25.3%
  • Pharmacology, Toxicology and Pharmaceutics2.8%
  • Computer Science2.1%
  • Agricultural and Biological Sciences1.6%
  • その他4.7%

トピック

  • Synthesis and biological activity5.4%
  • Microbial Natural Products and Biosynthesis4.8%
  • Cancer Treatment and Pharmacology4.3%
  • Microtubule and mitosis dynamics4.2%
  • Marine Sponges and Natural Products3.4%
  • Cancer therapeutics and mechanisms3%
  • その他74.9%

共著者

全論文

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  1. Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

    著者: George R. Pettit, Sheo B. Singh, Ernest Hamel, C. Michael Lin, David S. Alberts, D. Garcia-Kendal - Cellular and Molecular Life Sciences 1989 被引用: 789

  2. Dolastatin 10, a powerful cytostatic peptide derived from a marine animal

    著者: Ruoli Bai, George R. Petit, Ernest Hamel - Biochemical Pharmacology 1990 被引用: 320

  3. Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development

    著者: Mudasir Nabi Peerzada, Ernest Hamel, Ruoli Bai, Claudiu T. Supuran, Amir Azam - Pharmacology & Therapeutics 2021 被引用: 66

  4. A brain-penetrant microtubule-targeting agent that disrupts hallmarks of glioma tumorigenesis

    著者: Eric A. Horne, Philippe Diaz, Patrick J. Cimino, Erik Jung, Cong Xu, Ernest Hamel, Michael Wagenbach, Debra K Kumasaka, Nicholas B. Wageling, Daniel Domínguez Azorín, Frank Winkler, Linda Wordeman, Eric C. Holland, Nephi Stella - Neuro-Oncology Advances 2020 被引用: 24

  5. Novel indole-pyrazole hybrids as potential tubulin-targeting agents; Synthesis, antiproliferative evaluation, and molecular modeling studies

    著者: Mohammed Hawash, Sezen Güntekin Ergün, Deniz Kahraman, Abdurrahman Olğaç, Ernest Hamel, Rengül Çetin-Atalay, Sultan Nacak Baytaş - Journal of Molecular Structure 2023 被引用: 32

  6. Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity

    著者: Edson dos Anjos dos Santos, Ernest Hamel, Ruoli Bai, James C. Burnett, Camila Santos Suniga Tozatti, Danielle Bogo, Renata Trentin Perdomo, Alexandra M. M. Antunes, M. Matilde Marques, Maria de F.C. Matos, Dênis Pires de Lima - Bioorganic & Medicinal Chemistry Letters 2013 被引用: 86

  7. Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6

    著者: George R. Pettit, Sheo B. Singh, Michael R. Boyd, Ernest Hamel, Robin K. Pettit, Jean M. Schmidt, Fiona Hogan - Journal of Medicinal Chemistry 1995 被引用: 391

  8. Discodermolide, A Cytotoxic Marine Agent That Stabilizes Microtubules More Potently Than Taxol,

    著者: Ernst ter Haar, Richard Kowalski, Ernest Hamel, Chii M. Lin, Ross E. Longley, Sarath P. Gunasekera, Herbert S. Rosenkranz, Billy W. Day - Biochemistry 1996 被引用: 381

  9. Structure and Absolute Stereochemistry of Hectochlorin, a Potent Stimulator of Actin Assembly

    著者: Brian L. Márquez, Karl Shawn Watts, Alex Yokochi, Mary Ann Roberts, Pascal Verdier‐Pinard, Jorge I. Jiménez, Ernest Hamel, Paul J. Scheuer, William H. Gerwick - Journal of Natural Products 2002 被引用: 179

  10. Antineoplastic Agents. 445. Synthesis and Evaluation of Structural Modifications of (Z)- and (E)-Combretastatin A-4

    著者: George R. Pettit, Monte R. Rhodes, Delbert L. Herald, Ernest Hamel, Jean M. Schmidt, Robin K. Pettit - Journal of Medicinal Chemistry 2005 被引用: 172

  11. EF24, a novel curcumin analog, disrupts the microtubule cytoskeleton and inhibits HIF-1

    著者: Shala L. Thomas, Diansheng Zhong, Wei Zhou, Sanna Malik, Dennis C. Liotta, James P. Snyder, Ernest Hamel, Paraskevi Giannakakou - Cell Cycle 2008 被引用: 115

  12. Bioreductively Activatable Prodrug Conjugates of Combretastatin A-1 and Combretastatin A-4 as Anticancer Agents Targeted toward Tumor-Associated Hypoxia

    著者: Blake A. Winn, Laxman Devkota, Bunnarack Kuch, Matthew T. MacDonough, Tracy E. Strecker, Yifan Wang, Zhe Shi, Jeni Gerberich, Deboprosad Mondal, Alejandro J. Ramirez, Ernest Hamel, David J. Chaplin, Peter D. Davis, Ralph P. Mason, Mary Lynn Trawick, Kevin G. Pinney - Journal of Natural Products 2020 被引用: 25

  13. 4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells

    著者: Domiziana Masci, Michela Puxeddu, Laura Di Magno, Michele D’Ambrosio, Anastasia Parisi, Marianna Nalli, Ruoli Bai, Antonio Coluccia, Pietro Sciò, Viviana Orlando, Sara D’Angelo, Stefano Biagioni, Andrea Urbani, Ernest Hamel, Alessio Nocentini, Serena Filiberti, Marta Turati, Roberto Ronca, Joanna Kopecka, Chiara Riganti, Cinzia Fionda, Rosa Bordone, Giorgia Della Rocca, Gianluca Canettieri, Claudiu T. Supuran, Romano Silvestri, Giuseppe La Regina - Journal of Medicinal Chemistry 2023 被引用: 15

  14. Activities of the Microtubule-stabilizing Agents Epothilones A and B with Purified Tubulin and in Cells Resistant to Paclitaxel (Taxol®)

    著者: Richard Kowalski, Paraskevi Giannakakou, Ernest Hamel - Journal of Biological Chemistry 1997 被引用: 512

  15. Isolation, Structure, and Synthesis of Combretastatins A-1 and B-1, Potent New Inhibitors of Microtubule Assembly, Derived from Combretum caffrum

    著者: George R. Pettit, Sheo B. Singh, Margaret L. Niven, Ernest Hamel, Jean M. Schmidt - Journal of Natural Products 1987 被引用: 322

  16. Evaluation of Antimitotic Agents by Quantitative Comparisons of Their Effects on the Polymerization of Purified Tubulin

    著者: Ernest Hamel - Cell Biochemistry and Biophysics 2003 被引用: 274

  17. Arylthioindole Inhibitors of Tubulin Polymerization. 3. Biological Evaluation, Structure−Activity Relationships and Molecular Modeling Studies

    著者: Giuseppe La Regina, Michael Edler, Andrea Brancale, Sahar Kandil, Antonio Coluccia, Francesco Piscitelli, Ernest Hamel, Gabriella Martino, Ruth Matesanz, J. Fernando Dı́az, A. Ivana Scovassi, Ennio Prosperi, Antonio Lavecchia, Ettore Novellino, Marino Artico, Romano Silvestri - Journal of Medicinal Chemistry 2007 被引用: 214

  18. Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia

    著者: Ruoli Bai, Susan Friedman, George R. Pettit, Ernest Hamel - Biochemical Pharmacology 1992 被引用: 127

  19. : Isolation and structure of halistatin 1 from the eastern Indian Ocean marine sponge Phakellia carteri

    著者: George R. Pettit, Rui Tan, Feng Gao, Michael D. Williams, Dennis L. Doubek, Michael R. Boyd, Jean M. Schmidt, Jean Chapuis, Ernest Hamel - The Journal of Organic Chemistry 1993 被引用: 112

  20. Design, Synthesis, and Biological Evaluation of 6-Substituted Thieno[3,2-d]pyrimidine Analogues as Dual Epidermal Growth Factor Receptor Kinase and Microtubule Inhibitors

    著者: Romeo Romagnoli, Filippo Prencipe, Paola Oliva, Stefania Baraldi, Pier Giovanni Baraldi, Santiago Schiaffino Ortega, Mariem Chayah, María Kimatrai Salvador, M Cara, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Roberto Ronca, Roberta Bortolozzi, Elena Mariotto, Elena Mattiuzzo, Giampietro Viola - Journal of Medicinal Chemistry 2019 被引用: 48

  21. Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor

    著者: Michela Puxeddu, Jianchao Wu, Ruoli Bai, Michele D’Ambrosio, Marianna Nalli, Antonio Coluccia, Simone Manetto, Alessia Ciogli, Domiziana Masci, Andrea Urbani, Cinzia Fionda, Sonia Coni, Rosa Bordone, Gianluca Canettieri, Chiara Bigogno, Giulio Dondio, Ernest Hamel, Te Liu, Romano Silvestri, Giuseppe La Regina - Journal of Medicinal Chemistry 2022 被引用: 23

  22. Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia

    著者: Michela Puxeddu, Hongliang Shen, Ruoli Bai, Antonio Coluccia, M Bufano, Marianna Nalli, Jessica Sebastiani, Diego Brancaccio, Eleonora Da Pozzo, Chiara Tremolanti, Claudia Martini, Viviana Orlando, Stefano Biagioni, Maria Stefania Sinicropi, Jessica Ceramella, Domenico Iacopetta, Addolorata Maria Luce Coluccia, Ernest Hamel, Te Liu, Romano Silvestri, Giuseppe La Regina - European Journal of Medicinal Chemistry 2021 被引用: 23

  23. Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents

    著者: Farhana Islam, Tasdique M. Quadery, Ruoli Bai, Lerin R. Luckett‐Chastain, Ernest Hamel, Michael A. Ihnat, Aleem Gangjee - Bioorganic & Medicinal Chemistry Letters 2021 被引用: 23

  24. Copper(II) Complexes with Isomeric Morpholine-Substituted 2-Formylpyridine Thiosemicarbazone Hybrids as Potential Anticancer Drugs Inhibiting Both Ribonucleotide Reductase and Tubulin Polymerization: The Morpholine Position Matters

    著者: Miljan N. M. Milunović, Katerina Ohui, Iuliana Besleaga, Tatsiana V. Petrasheuskaya, Orsolya Dömötör, Éva A. Enyedy, Denisa Darvasiová, Peter Rapta, Zuzana Barbieriková, Daniel Végh, Szilárd Tóth, Judit Tóth, Nóra Kucsma, Gergely Szakács, Ana Popović‐Bijelić, Ayesha Zafar, Jóhannes Reynisson, Anatoly D. Shutalev, Ruoli Bai, Ernest Hamel, Vladimir B. Arion - Journal of Medicinal Chemistry 2024 被引用: 18