Jay D. Horton
1993–2024 年に発表
- 90
- 論文数
- 44,978
- 被引用数
- 79
- h 指数
- 89
- i10 指数
被引用数
引用元
国・地域
機関
分野
- Medicine62.2%
- Biochemistry, Genetics and Molecular Biology28.3%
- Immunology and Microbiology2%
- Neuroscience2%
- Nursing1.8%
- Agricultural and Biological Sciences1.5%
- その他2.2%
トピック
- Liver Disease Diagnosis and Treatment9.1%
- Cholesterol and Lipid Metabolism5.2%
- Lipoproteins and Cardiovascular Health4.8%
- Diet, Metabolism, and Disease3.6%
- Peroxisome Proliferator-Activated Receptors3.4%
- Diabetes, Cardiovascular Risks, and Lipoproteins3.2%
- その他70.7%
共著者
- Robert E. Hammer20
- Young-Ah Moon13
- Iichiro Shimomura12
- Joseph L. Goldstein12
- Michael S. Brown12
- Guosheng Liang9
- Helen H. Hobbs9
- Hitoshi Shimano9
- Jonathan C. Cohen9
- Norma N. Anderson8
- Thomas A. Lagace8
- Yuriy K. Bashmakov8
- Jeffrey D. Browning7
- Chai-Wan Kim5
- J L Goldstein5
- Markey McNutt5
- Philipp E. Scherer5
- Shawn C. Burgess5
- Jeffrey G. McDonald4
- Kevin Fitzgerald4
- Sahng Wook Park4
- Vı́ctor Cortés4
- Xiaorong Fu4
- Abhimanyu Garg3
全論文
- Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel
著者: Brian A. Ference, Henry N. Ginsberg, Ian Graham, Kausik K. Ray, Chris J. Packard, Éric Bruckert, Robert A. Hegele, Ronald M. Krauss, Frederick J. Raal, Heribert Schunkert, Gerald F. Watts, Jan Borén, Sergio Fazio, Jay D. Horton, L. Masana, Stephen J. Nicholls, Børge G. Nordestgaard, Bart van de Sluis, Marja‐Riitta Taskinen, Lâle Tokgözoğlu, Ulf Landmesser, Ulrich Laufs, Olov Wiklund, Jane K. Stock, M. John Chapman, Alberico L. Catapano - European Heart Journal 2017 被引用: 3,840
- Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel
著者: Jan Borén, M. John Chapman, Ronald M. Krauss, Chris J. Packard, Jacob Fog Bentzon, Christoph J. Binder, Mat J.A.P. Daemen, Linda L. Demer, Robert A. Hegele, Stephen J. Nicholls, Børge G. Nordestgaard, Gerald F. Watts, Éric Bruckert, Sergio Fazio, Brian A. Ference, Ian Graham, Jay D. Horton, Ulf Landmesser, Ulrich Laufs, L. Masana, Gerard Pasterkamp, Frederick J. Raal, Kausik K. Ray, Heribert Schunkert, Marja‐Riitta Taskinen, Bart van de Sluis, Olov Wiklund, Lâle Tokgözoğlu, Alberico L. Catapano, Henry N. Ginsberg - European Heart Journal 2020 被引用: 1,527
- Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: A Scientific Statement From the American Heart Association
著者: P. Barton Duell, Francine K. Welty, Michael Miller, Alan Chait, Gmerice Hammond, Zahid Ahmad, David E. Cohen, Jay D. Horton, Gregg S. Pressman, Peter P. Toth - Arteriosclerosis Thrombosis and Vascular Biology 2022 被引用: 645
- SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
著者: Jay D. Horton, Joseph L. Goldstein, Michael S. Brown - Journal of Clinical Investigation 2002 被引用: 4,316
- Human Fatty Liver Disease: Old Questions and New Insights
著者: Jonathan C. Cohen, Jay D. Horton, Helen H. Hobbs - Science 2011 被引用: 2,088
- Acetate Dependence of Tumors
著者: Sarah A. Comerford, Zhi‐Guang Huang, Xinlin Du, Yun Wang, Ling Cai, Agnes K. Witkiewicz, Holly C. Walters, Mohammed Noor Tantawy, Allie Fu, H. Charles Manning, Jay D. Horton, Robert E. Hammer, Steven L. McKnight, Benjamin P. Tu - Cell 2014 被引用: 695
- Prevalence of Hepatic Steatosis in An Urban Population in the United States: Impact of Ethnicity
著者: Jeffrey D. Browning, Lidia S. Szczepaniak, Robert L. Dobbins, Pamela Nuremberg, Jay D. Horton, Jonathan C. Cohen, Scott M. Grundy, Helen H. Hobbs - Hepatology 2004 被引用: 3,664
- A Highly Durable RNAi Therapeutic Inhibitor of PCSK9
著者: Kevin Fitzgerald, Suellen White, Anna Borodovsky, Brian R. Bettencourt, Andrew Strahs, Valerie A. Clausen, Peter Wijngaard, Jay D. Horton, Jörg Täubel, Ashley Brooks, Chamikara Fernando, Robert S. Kauffman, David Kallend, Akshay Vaishnaw, Amy Simon - New England Journal of Medicine 2016 被引用: 760
- Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation
著者: Chai-Wan Kim, Carol Addy, Jun Kusunoki, Norma N. Anderson, Stanisław Deja, Xiaorong Fu, Shawn C. Burgess, Li Cai, Marcie Ruddy, Manu V. Chakravarthy, Steve Previs, Stuart Milstein, Kevin Fitzgerald, David E. Kelley, Jay D. Horton - Cell Metabolism 2017 被引用: 413
- Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
著者: Jay D. Horton, Nila Shah, Janet A. Warrington, Norma N. Anderson, Sahng Wook Park, Michael S. Brown, Joseph L. Goldstein - National Academy of Sciences, Proceedings of the National Academy of Sciences 2003 被引用: 1,444
- Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism
著者: Heather A. Ferris, Rachel J. Perry, Gabriela Moreira, Gerald I. Shulman, Jay D. Horton, C. Ronald Kahn - National Academy of Sciences, Proceedings of the National Academy of Sciences 2017 被引用: 238
- Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation
著者: Dawei Zhang, Thomas A. Lagace, Rita Garuti, Zhenze Zhao, Meghan McDonald, Jay D. Horton, Jonathan C. Cohen, Helen H. Hobbs - Journal of Biological Chemistry 2007 被引用: 784
- Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
著者: Kevin Fitzgerald, Maria Frank-Kamenetsky, Svetlana Shulga‐Morskaya, Abigail Liebow, Brian R. Bettencourt, Jessica E. Sutherland, Renta Hutabarat, Valerie A. Clausen, Verena Karsten, Jeffrey Cehelsky, Saraswathy V. Nochur, Victor Kotelianski, Jay D. Horton, Timothy Mant, Joseph Chiesa, James M. Ritter, Malathy Munisamy, Akshay Vaishnaw, Jared Gollob, Amy Simon - The Lancet 2013 被引用: 574
- DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER
著者: Shunxing Rong, Mingfeng Xia, Gonçalo Vale, Simeng Wang, Chai-Wan Kim, Shili Li, Jeffrey G. McDonald, Arun Radhakrishnan, Jay D. Horton - Cell Metabolism 2024 被引用: 91
- Interplay between ChREBP and SREBP-1c coordinates postprandial glycolysis and lipogenesis in livers of mice
著者: Albert G. Linden, Shili Li, Hwa Young Choi, Fei Fang, Masashi Fukasawa, Kosaku Uyeda, Robert E. Hammer, Jay D. Horton, Luke J. Engelking, Guosheng Liang - Journal of Lipid Research 2018 被引用: 230
- The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals
著者: Young-Ah Moon, Guosheng Liang, Xuefen Xie, Maria Frank-Kamenetsky, Kevin Fitzgerald, Victor Koteliansky, Michael S. Brown, Joseph L. Goldstein, Jay D. Horton - Cell Metabolism 2012 被引用: 316
- CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
著者: Paulina Bartuzi, Daniel D. Billadeau, Robert P. Favier, Shunxing Rong, Daphne Dekker, Alina Fedoseienko, Hille Fieten, Melinde Wijers, Johannes H.M. Levels, Nicolette Huijkman, Niels Kloosterhuis, Henk van der Molen, Gemma Brufau, Albert K. Groen, Alison M. Elliott, Jan Albert Kuivenhoven, Barbara Plecko, Gernot Grangl, Julie McGaughran, Jay D. Horton, Ezra Burstein, Marten H. Hofker, Bart van de Sluis - Nature Communications 2016 被引用: 231
- Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice
著者: Shunxing Rong, Vı́ctor Cortés, Shirya Rashid, Norma N. Anderson, Jeffrey G. McDonald, Guosheng Liang, Young-Ah Moon, Robert E. Hammer, Jay D. Horton - eLife 2017 被引用: 136
- PCSK9: a convertase that coordinates LDL catabolism
著者: Jay D. Horton, Jonathan C. Cohen, Helen H. Hobbs - Journal of Lipid Research 2008 被引用: 631
- Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and inlivers of parabiotic mice
著者: Thomas A. Lagace, David E. Curtis, Rita Garuti, Markey McNutt, Sahng Wook Park, Heidi Prather, Norma N. Anderson, Y K Ho, Robert E. Hammer, Jay D. Horton - Journal of Clinical Investigation 2006 被引用: 671
- Molecular Characterization of Loss-of-Function Mutations in PCSK9 and Identification of a Compound Heterozygote
著者: Zhenze Zhao, Yetsa Tuakli-Wosornu, Thomas A. Lagace, Lisa N. Kinch, Nicholas V. Grishin, Jay D. Horton, Jonathan C. Cohen, Helen H. Hobbs - The American Journal of Human Genetics 2006 被引用: 633
- Genetic and Metabolic Determinants of Plasma PCSK9 Levels
著者: Susan G. Lakoski, Thomas A. Lagace, Jonathan C. Cohen, Jay D. Horton, Helen H. Hobbs - The Journal of Clinical Endocrinology & Metabolism 2009 被引用: 532
- Molecular basis for LDL receptor recognition by PCSK9
著者: Hyock Joo Kwon, Thomas A. Lagace, Markey McNutt, Jay D. Horton, J. Deisenhofer - National Academy of Sciences, Proceedings of the National Academy of Sciences 2008 被引用: 414
- Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability
著者: Stanisław Deja, Justin A. Fletcher, Chai-Wan Kim, Blanka Kucejová, Xiaorong Fu, Monika Mizerska, Morgan Villegas, Natalia Pudełko‐Malik, Nicholas Browder, Melissa R. Iñigo, Cameron J. Menezes, Prashant Mishra, Eric D. Berglund, Jeffrey D. Browning, John P. Thyfault, Jamey D. Young, Jay D. Horton, Shawn C. Burgess - Cell Metabolism 2024 被引用: 59
