Ken Inoki
1999–2025 年に発表
- 61
- 論文数
- 22,562
- 被引用数
- 52
- h 指数
- 57
- i10 指数
被引用数
引用元
国・地域
機関
分野
- Biochemistry, Genetics and Molecular Biology51%
- Medicine40.3%
- Neuroscience3.9%
- Immunology and Microbiology2.4%
- Agricultural and Biological Sciences0.9%
- Environmental Science0.3%
- その他1.2%
トピック
- PI3K/AKT/mTOR signaling in cancer7.9%
- Autophagy in Disease and Therapy6.9%
- Metabolism, Diabetes, and Cancer5%
- Pancreatic function and diabetes2.9%
- Cancer, Hypoxia, and Metabolism2.3%
- Protein Kinase Regulation and GTPase Signaling1.7%
- その他73.3%
共著者
- Kun‐Liang Guan32
- Hiroyuki Mori7
- Tsuneo Ikenoue7
- Yong Li7
- Ormond A. MacDougald6
- Sei Yoshida6
- Sungki Hong6
- Tsukasa Suzuki6
- Yao Yao6
- Qian Yang4
- Avani Kamath3
- Daisuke Koya3
- Dave Bridges3
- David J. Kwiatkowski3
- Diane C. Fingar3
- Junying Wang3
- Matthias Kretzler3
- Michael N. Corradetti3
- Tianqing Zhu3
- Tobias B. Huber3
- Aaron Thurman2
- Akira Nishii2
- Alan R. Saltiel2
- Ayaka Inoki2
全論文
- TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
著者: Ken Inoki, Tianqing Zhu, Kun‐Liang Guan - Cell 2003 被引用: 3,913
- TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
著者: Ken Inoki, Yong Li, Tianquan Zhu, Jun Wu, Kun‐Liang Guan - Nature Cell Biology 2002 被引用: 3,056
- Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
著者: Ken Inoki, Yong Li, Tian Xu, Kun‐Liang Guan - Genes & Development 2003 被引用: 1,915
- AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets
著者: Ken Inoki, Joungmok Kim, Kun‐Liang Guan - The Annual Review of Pharmacology and Toxicology 2011 被引用: 792
- Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes
著者: Masako Narita, Andrew Young, Satoko Arakawa, Shamith Samarajiwa, Takayuki Nakashima, Sei Yoshida, Sungki Hong, Lorraine Berry, Stefanie Reichelt, Manuela Ferreira, Simon Tavaré, Ken Inoki, Shigeomi Shimizu, Masashi Narita - Science 2011 被引用: 597
- SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth-onset type 2 diabetes
著者: Jennifer A. Schaub, Fadhl Alakwaa, Phillip J. McCown, Abhijit S. Naik, Viji Nair, Sean Eddy, Rajasree Menon, Edgar A. Otto, Dawit Demeke, John R. Hartman, Damian Fermin, Christopher L. O’Connor, Lalita Subramanian, Markus Bitzer, Roger K. Harned, Patricia Ladd, Laura Pyle, Subramaniam Pennathur, Ken Inoki, Jeffrey B. Hodgin, Frank C. Brosius, Robert G. Nelson, Matthias Kretzler, Petter Bjornstad - Journal of Clinical Investigation 2023 被引用: 107
- Nutrient-sensing mTORC1 and AMPK pathways in chronic kidney diseases
著者: Christopher Huynh, Jaewhee Ryu, Jooho Lee, Ayaka Inoki, Ken Inoki - Nature Reviews Nephrology 2022 被引用: 93
- TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
著者: Ken Inoki, Hongjiao Ouyang, Tianqing Zhu, Charlotta Lindvall, Yian Wang, Xiaojie Zhang, Qian Yang, Christina N. Bennett, Yuko Harada, Kryn Stankunas, Cun-Yu Wang, Xi He, Ormond A. MacDougald, Ming You, Bart O. Williams, Kun‐Liang Guan - Cell 2006 被引用: 1,396
- AMPK directly activates mTORC2 to promote cell survival during acute energetic stress
著者: Dubek Kazyken, Brian Magnuson, Çağrı Bodur, Hugo A. Acosta-Jaquez, Deqiang Zhang, Xin Tong, Tammy M. Barnes, Gabrielle K. Steinl, Nicole Patterson, Christopher Altheim, Naveen Sharma, Ken Inoki, Gregory D. Cartee, Dave Bridges, Lei Yin, Steven M. Riddle, Diane C. Fingar - Science Signaling 2019 被引用: 224
- Role of mTOR in podocyte function and diabetic nephropathy in humans and mice
著者: Markus Gödel, Björn Hartleben, Nadja Herbach, Shuya Liu, Stefan Zschiedrich, Shun Lu, Andrea Debreczeni-Mór, Maja T. Lindenmeyer, Maria-Pia Rastaldi, Götz Hartleben, Thorsten Wiech, Alessia Fornoni, Robert G. Nelson, Matthias Kretzler, Rüdiger Wanke, Hermann Pavenstädt, Dontscho Kerjaschki, Clemens D. Cohen, Michael N. Hall, Markus A. Rüegg, Ken Inoki, Gerd Walz, Tobias B. Huber - Journal of Clinical Investigation 2011 被引用: 543
- mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice
著者: Ken Inoki, Hiroyuki Mori, Junying Wang, Tsukasa Suzuki, SungKi Hong, Sei Yoshida, Simone M. Blattner, Tsuneo Ikenoue, Markus A. Rüegg, Michael N. Hall, David J. Kwiatkowski, Maria Pia Rastaldi, Tobias B. Huber, Matthias Kretzler, Lawrence B. Holzman, Roger C. Wiggins, Kun‐Liang Guan - Journal of Clinical Investigation 2011 被引用: 531
- Glycolytic Enzymes Coalesce in G Bodies under Hypoxic Stress
著者: Meiyan Jin, Gregory G. Fuller, Ting Han, Yao Yao, Amelia F. Alessi, Mallory Freeberg, Nathan Roach, James J. Moresco, Alla Karnovsky, Misuzu Baba, John R. Yates, Aaron D. Gitler, Ken Inoki, Daniel J. Klionsky, John K. Kim - Cell Reports 2017 被引用: 212
- mTORC1 underlies age‐related muscle fiber damage and loss by inducing oxidative stress and catabolism
著者: Huibin Tang, Ken Inoki, Susan V. Brooks, Hideki Okazawa, Myung Lee, Junying Wang, Michael Kim, Catherine L. Kennedy, Peter Macpherson, Xuhuai Ji, Sabrina Van Roekel, Danielle Fraga, Kun Wang, Jinguo Zhu, Yoyo Wang, Z. Dave Sharp, Richard A. Miller, Thomas A. Rando, Daniel Goldman, Kun‐Liang Guan, Joseph B. Shrager - Aging Cell 2019 被引用: 184
- ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS
著者: Angela Alexander, Sheng-Li Cai, Jinhee Kim, Adrian Nañez, Mustafa Şahin, Kirsteen H. Maclean, Ken Inoki, Kun‐Liang Guan, Jianjun Shen, Maria D. Person, Donna F. Kusewitt, Gordon B. Mills, Michael B. Kastan, Cheryl Lyn Walker - National Academy of Sciences, Proceedings of the National Academy of Sciences 2010 被引用: 709
- LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
著者: Sungki Hong, Mallory Freeberg, Ting Han, Avani Kamath, Yao Yao, Tomoko Fukuda, Tsukasa Suzuki, John K. Kim, Ken Inoki - eLife 2017 被引用: 213
- Emerging role of autophagy in kidney function, diseases and aging
著者: Tobias B. Huber, Charles L. Edelstein, Björn Hartleben, Ken Inoki, Man Jiang, Daisuke Koya, Shinji Kume, Wilfred Lieberthal, Nicolas Pallet, Alejandro Quiroga, Kameswaran Ravichandran, Katalin Suszták, Sei Yoshida, Zheng Dong - Autophagy 2012 被引用: 251
- ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity
著者: Lu Liu, Ayaka Inoki, Kelly Fan, Fengbiao Mao, Guojun Shi, Xi Jin, Meiling Zhao, Gina M. Ney, Morgan H. Jones, Shengyi Sun, Yali Dou, Ken Inoki, Ling Qi, Qing Li - Blood 2020 被引用: 65
- Dysregulation of the TSC-mTOR pathway in human disease
著者: Ken Inoki, Michael N. Corradetti, Kun‐Liang Guan - Nature Genetics 2004 被引用: 980
- Inhibition of AMPK Catabolic Action by GSK3
著者: Tsukasa Suzuki, Dave Bridges, Daisuke Nakada, Georgios Skiniotis, Sean J. Morrison, Jiandie D. Lin, Alan R. Saltiel, Ken Inoki - Molecular Cell 2013 被引用: 224
- Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
著者: Tsuneo Ikenoue, Ken Inoki, Qian Yang, Xiaoming Zhou, Kun‐Liang Guan - The EMBO Journal 2008 被引用: 608
- Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
著者: Michael N. Corradetti, Ken Inoki, Nabeel Bardeesy, Ronald A. DePinho, Kun‐Liang Guan - Genes & Development 2004 被引用: 565
- PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity
著者: Junya Hasegawa, Emi Tokuda, Yao Yao, Takehiko Sasaki, Ken Inoki, Lois S. Weisman - Molecular Biology of the Cell 2022 被引用: 40
- Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
著者: Qian Yang, Ken Inoki, Tsuneo Ikenoue, Kun‐Liang Guan - Genes & Development 2006 被引用: 522
- mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases
著者: Huibin Tang, Ken Inoki, Myung Lee, Erika Wright, Andy Khuong, Amanda Khuong, Sista Sugiarto, Matthew Garner, Jihye Paik, Ronald A. DePinho, Daniel Goldman, Kun‐Liang Guan, Joseph B. Shrager - Science Signaling 2014 被引用: 151
