Manfred T. Reetz
1972–2025 年に発表
- 184
- 論文数
- 35,626
- 被引用数
- 116
- h 指数
- 183
- i10 指数
被引用数
引用元
国・地域
機関
分野
- Biochemistry, Genetics and Molecular Biology50.8%
- Chemistry23.8%
- Materials Science8.4%
- Medicine3.7%
- Pharmacology, Toxicology and Pharmaceutics3.5%
- Engineering3.4%
- その他6.4%
トピック
- Enzyme Catalysis and Immobilization13.9%
- Microbial Metabolic Engineering and Bioproduction7.5%
- Chemical Synthesis and Analysis4.6%
- Asymmetric Hydrogenation and Catalysis3.4%
- Protein Structure and Dynamics2.2%
- Pharmacogenetics and Drug Metabolism2%
- その他66.4%
共著者
- Karl‐Erich Jaeger14
- Zhoutong Sun14
- Albin Zonta11
- Aitao Li10
- Guangyue Li9
- José Daniel Carballeira9
- Carlos G. Acevedo‐Rocha8
- Ge Qu8
- Joaquı́n Sanchis8
- Marco Bocola8
- Gerlinde Mehler7
- Klaus Schimossek7
- Andreas Taglieber6
- Andreas Vogel6
- Jiahai Zhou6
- Michael Becker6
- Richard Lonsdale6
- Frank Schulz5
- Gunther Lohmer5
- Jian‐bo Wang5
- Alfred Deege4
- Andrea J. Maichele4
- Andreas Meiswinkel4
- Dongxing Zha4
全論文
- The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes
著者: Ge Qu, Aitao Li, Carlos G. Acevedo‐Rocha, Zhoutong Sun, Manfred T. Reetz - Angewandte Chemie International Edition 2019 被引用: 469
- Utility of B-Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability
著者: Zhoutong Sun, Qian Liu, Ge Qu, Yan Feng, Manfred T. Reetz - Chemical Reviews 2019 被引用: 541
- Iterative saturation mutagenesis (ISM) for rapid directed evolution of functional enzymes
著者: Manfred T. Reetz, José Daniel Carballeira - Nature Protocols 2007 被引用: 866
- Engineered enzymes for the synthesis of pharmaceuticals and other high-value products
著者: Manfred T. Reetz, Ge Qu, Zhoutong Sun - Nature Synthesis 2024 被引用: 154
- Stereodivergent Protein Engineering of a Lipase To Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters
著者: Jian Xu, Yixin Cen, Warispreet Singh, Jiajie Fan, Lian Wu, Xianfu Lin, Jiahai Zhou, Meilan Huang, Manfred T. Reetz, Qi Wu - Journal of the American Chemical Society 2019 被引用: 207
- Reducing Codon Redundancy and Screening Effort of Combinatorial Protein Libraries Created by Saturation Mutagenesis
著者: Sabrina Kille, Carlos G. Acevedo‐Rocha, Loreto P. Parra, Zhigang Zhang, Diederik J. Opperman, Manfred T. Reetz, Juan Pablo Acevedo - ACS Synthetic Biology 2012 被引用: 358
- Expanding the Range of Substrate Acceptance of Enzymes: Combinatorial Active‐Site Saturation Test
著者: Manfred T. Reetz, Marco Bocola, José Daniel Carballeira, Dongxing Zha, Andreas Vogel - Angewandte Chemie 2005 被引用: 504
- Biocatalysis in Organic Chemistry and Biotechnology: Past, Present, and Future
著者: Manfred T. Reetz - Journal of the American Chemical Society 2013 被引用: 762
- Pervasive cooperative mutational effects on multiple catalytic enzyme traits emerge via long-range conformational dynamics
著者: Carlos G. Acevedo‐Rocha, Aitao Li, Lorenzo D’Amore, Sabrina Hoebenreich, Joaquı́n Sanchis, Paul Lubrano, Matteo P. Ferla, Marc Garcia‐Borràs, Sílvia Osuna, Manfred T. Reetz - Nature Communications 2021 被引用: 123
- A machine learning approach for reliable prediction of amino acid interactions and its application in the directed evolution of enantioselective enzymes
著者: Frédéric Cadet, Nicolas Fontaine, Guangyue Li, Joaquı́n Sanchis, Matthieu Ng Fuk Chong, Rudy Pandjaitan, Iyanar Vetrivel, Bernard Offmann, Manfred T. Reetz - Scientific Reports 2018 被引用: 142
- Laboratory Evolution of Stereoselective Enzymes: A Prolific Source of Catalysts for Asymmetric Reactions
著者: Manfred T. Reetz - Angewandte Chemie International Edition 2010 被引用: 533
- Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution
著者: Sabrina Kille, Felipe E. Zilly, Juan Pablo Acevedo, Manfred T. Reetz - Nature Chemistry 2011 被引用: 413
- Structure-Guided Triple-Code Saturation Mutagenesis: Efficient Tuning of the Stereoselectivity of an Epoxide Hydrolase
著者: Zhoutong Sun, Richard Lonsdale, Lian Wu, Guangyue Li, Aitao Li, Jian‐bo Wang, Jiahai Zhou, Manfred T. Reetz - ACS Catalysis 2016 被引用: 135
- Can Machine Learning Revolutionize Directed Evolution of Selective Enzymes?
著者: Guangyue Li, Yijie Dong, Manfred T. Reetz - Advanced Synthesis & Catalysis 2019 被引用: 125
- Making Enzymes Suitable for Organic Chemistry by Rational Protein Design
著者: Manfred T. Reetz - ChemBioChem 2022 被引用: 70
- Learning from Protein Engineering by Deconvolution of Multi‐Mutational Variants
著者: Frank Hollmann, Joaquı́n Sanchis, Manfred T. Reetz - Angewandte Chemie International Edition 2024 被引用: 40
- Catalytic Asymmetric Reduction of Difficult-to-Reduce Ketones: Triple-Code Saturation Mutagenesis of an Alcohol Dehydrogenase
著者: Zhoutong Sun, Richard Lonsdale, Adriana Ilie, Guang‐Yue Li, Jiahai Zhou, Manfred T. Reetz - ACS Catalysis 2016 被引用: 141
- Regio‐ and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants
著者: Aitao Li, Carlos G. Acevedo‐Rocha, Lorenzo D’Amore, Jinfeng Chen, Yaqin Peng, Marc Garcia‐Borràs, Chenghua Gao, Jinmei Zhu, Harry Rickerby, Sílvia Osuna, Jiahai Zhou, Manfred T. Reetz - Angewandte Chemie 2020 被引用: 136
- Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution
著者: Yixin Cen, Warispreet Singh, M Arkin, Thomas S. Moody, Meilan Huang, Jiahai Zhou, Qi Wu, Manfred T. Reetz - Nature Communications 2019 被引用: 100
- Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles
著者: Jun‐Kuan Li, Ge Qu, Xu Li, Yuchen Tian, Chengsen Cui, Fa‐Guang Zhang, Wuyuan Zhang, Jun‐An Ma, Manfred T. Reetz, Zhoutong Sun - Nature Communications 2022 被引用: 31
- Bacterial Biocatalysts: Molecular Biology, Three-Dimensional Structures, and Biotechnological Applications of Lipases
著者: K-E. Jaeger, Bauke W. Dijkstra, Manfred T. Reetz - Annual Review of Microbiology 1999 被引用: 1,085
- Addressing the Numbers Problem in Directed Evolution
著者: Manfred T. Reetz, Daniel Kahakeaw, Renate Lohmer - ChemBioChem 2008 被引用: 440
- P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping
著者: Carlos G. Acevedo‐Rocha, Charles G. Gamble, Richard Lonsdale, Aitao Li, Nathalie Nett, Sabrina Hoebenreich, Julia B. Lingnau, C. Wirtz, Christophe Farès, Heike Hinrichs, Alfred Deege, Adrian J. Mulholland, Yuval Nov, David Leys, Kirsty J. McLean, Andrew W. Munro, Manfred T. Reetz - ACS Catalysis 2018 被引用: 172
- Iterative Saturation Mutagenesis on the Basis of B Factors as a Strategy for Increasing Protein Thermostability
著者: Manfred T. Reetz, José Daniel Carballeira, Andreas Vogel - Angewandte Chemie 2006 被引用: 484
