Osteocyte calcium signals encode strain magnitude and loading frequency in vivo

著者: Karl J. Lewis, Dorra Frikha-Benayed, Joyce Louie, Samuel J. Stephen, David C. Spray, Mia M. Thi, Zeynep Şeref-Ferlengez, Robert J. Majeska, Sheldon Weinbaum, Mitchell B. Schaffler - Proceedings of the National Academy of Sciences, PNAS 2017 被引用: 112

Significance Osteocytes are thought to be the major regulator of bone mechanosensation events. However, little is known about how osteocytes in vivo acutely respond to tissue-level mechanical loading. We report here a technique for the direct in vivo observation of osteocyte calcium signaling events with simultaneous whole bone loading. Our results demonstrate that osteocyte populations integrate mechanical signals by altering the number of responding cells and that this effect is dependent on loading frequency.