Adaptive deep brain stimulation for Parkinson's disease demonstrates reduced speech side effects compared to conventional stimulation in the acute setting

著者: Simon Little, Elina Tripoliti, Martijn Beudel, Alek Pogosyan, Hayriye Cagnan, Damian M. Herz, Sven Bestmann, Tipu Z. Aziz, Binith Cheeran, Ludvic Zrinzo, Marwan Hariz, Jonathan Hyam, Patricia Limousin, Tom Foltynie, Peter Brown - Journal of Neurology Neurosurgery & Psychiatry 2016 被引用: 258

Deep brain stimulation (DBS) for Parkinson's disease (PD) is currently limited by costs, partial efficacy and surgical and stimulation-related side effects. This has motivated the development of adaptive DBS (aDBS) whereby stimulation is automatically adjusted according to a neurophysiological biomarker of clinical state, such as β oscillatory activity (12–30 Hz). aDBS has been studied in parkinsonian primates and patients and has been reported to be more energy efficient and effective in alleviating motor symptoms than conventional DBS (cDBS) at matched amplitudes.