NOD2 Deficiency Promotes Intestinal CD4+ T Lymphocyte Imbalance, Metainflammation, and Aggravates Type 2 Diabetes in Murine Model

著者: Daniela Carlos, Malena M. Pérez, Jefferson Antônio Leite, Fernanda A. Rocha, Larissa M. S. Martins, Camila A. Pereira, Thais Fernanda de Campos Fraga‐Silva, Taís A. Pucci, Simone G. Ramos, Niels Olsen Saraiva Câmara, Vânia Luiza Deperon Bonato, Rita C. Tostes, João S. Silva - Frontiers in Immunology 2020 被引用: 30

genera in these mice compared to HFD-fed WT mice. These alterations were associated with disrupted tight-junctions expression, augmented serum LPS, and bacterial translocation into VAT. Overall, NOD2 activation is required for a protective Th17 over Th1 immunity in the gut, which seems to decrease gram-negative bacteria outgrowth in gut microbiota, attenuating the endotoxemia, metainflammation, and protecting against obesity-induced T2D.