Single-cell analysis reveals a nestin + tendon stem/progenitor cell population with strong tenogenic potentiality

著者: Zi Yin, Jiajie Hu, Long Yang, Zefeng Zheng, Chengrui An, Bingbing Wu, Can Zhang, Weiliang Shen, Huanhuan Liu, Jialin Chen, Boon Chin Heng, Guoji Guo, Xiao Chen, Hongwei Ouyang - Science Advances 2016 被引用: 151

TSPCs. Knockdown of nestin expression in TSPCs suppressed their clonogenic capacity and reduced their tenogenic potential significantly both in vitro and in vivo. Hence, these findings provide new insights into the identification of subpopulations of TSPCs and illustrate the crucial roles of nestin in TSPC fate decisions and phenotype maintenance, which may assist in future therapeutic strategies to treat tendon disease.