Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria

著者: Samuel J. Balin, Matteo Pellegrini, Eynav Klechevsky, Sohui T. Won, David I. Weiss, Aaron Choi, Joshua K. Hakimian, Jing Lü, Marîa Teresa Ochoa, Barry R. Bloom, Lewis L. Lanier, Steffen Stenger, Robert L. Modlin - Science Immunology 2018 被引用: 93

CTLs expressing granzyme B, perforin, and granulysin, as well as the activating NK receptor NKG2C, represent a population of "antimicrobial CTLs" (amCTLs) capable of T cell receptor (TCR)-dependent and TCR-independent release of cytotoxic granule proteins that mediate antimicrobial activity.