A nontoxic pain killer designed by modeling of pathological receptor conformations

著者: Viola Spahn, Giovanna Del Vecchio, Dominika Łabuz, Antonio Rodríguez‐Gaztelumendi, Nicolas Massaly, Julia Temp, Vedat Durmaz, Peggy Sabri, Marco Reidelbach, Halina Machelska, Marcus Weber, Christoph Stein - Science 2017 被引用: 228

A pain killer without side effects Opioids are very strong and effective pain killers. However, they also have a range of well-known side effects and can cause addiction. Painful conditions such as inflammation or trauma are often associated with localized tissue acidification. Spahn et al. designed a novel opioid receptor agonist that, unlike clinically used opioids, best activates the receptors in such acidified tissues. In rat models of inflammatory pain, the new drug exerted strong pain relief essentially without the side effects of standard opioids. Science , this issue p. 966