Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese women

著者: Kelly E. Mercer, Adrianna Maurer, Lindsay Pack, Kikumi D. Ono‐Moore, Beverly J. Spray, Caitlin Campbell, Carol J. Chandler, Dustin J. Burnett, Elaine C. Souza, Gretchen A. Casazza, Nancy L. Keim, John W. Newman, Gary R. Hunter, Jose Fernadez, W. Timothy Garvey, Mary‐Ellen Harper, Charles L. Hoppel, Sean H. Adams, John P. Thyfault - American Journal of Physiology-Endocrinology and Metabolism 2021 被引用: 42

Exercise and weight loss in previously sedentary, insulin-resistant women facilitates a significant improvement in insulin sensitivity and fitness that may be linked to changes in bile acid metabolism. Diet-induced weight loss plus exercise-induced increases in fitness promote greater postabsorptive bile acid synthesis while also sensitizing the bile acid metabolic system to feedback inhibition during a glucose challenge when glucose and insulin are elevated.