METTL6 is a tRNA m 3 C methyltransferase that regulates pluripotency and tumor cell growth

著者: V. V. Ignatova, Steffen Kaiser, Jessica Ho, Xinyang Bing, Paul Stolz, Ying Xim Tan, Chee Leng Lee, Florence Pik Hoon Gay, Palma Rico Lastres, Raffaele Gerlini, Birgit Rathkolb, Juan Antonio Aguilar‐Pimentel, Adrián Sanz‐Moreno, Tanja Klein‐Rodewald, Julia Calzada‐Wack, Emil Ibragimov, Magdalena Valenta, Saulius Lukauskas, Andrea Pavesi, Susan Marschall, Stefanie Leuchtenberger, Helmut Fuchs, Valérie Gailus‐Durner, Martin Hrabě de Angelis, Sebastian Bultmann, Oliver J. Rando, Ernesto Guccione, Stefanie Kellner, Robert Schneider - Science Advances 2020 被引用: 103

knockout results in reduced energy expenditure. We reveal a previously unknown pathway in the maintenance of translation efficiency with a role in maintaining stem cell self-renewal, as well as impacting tumor cell growth profoundly.