Drosophila Antimicrobial Peptides and Lysozymes Regulate Gut Microbiota Composition and Abundance

著者: Alice Marra, Mark A. Hanson, Shu Kondo, Berra Erkoşar, Bruno Lemaître - mBio 2021 被引用: 169

This study advances current knowledge in the field of host-microbe interactions by demonstrating that the two families of immune effectors, antimicrobial peptides and lysozymes, actively regulate the gut microbiota composition and abundance. Consequences of the loss of these antimicrobial peptides and lysozymes are exacerbated during aging, and their loss contributes to increased microbiota abundance and shifted composition in old flies. This work shows that immune effectors, typically associated with resistance to pathogenic infections, also help shape the beneficial gut community, consistent with the idea that host-symbiont interactions use the same "language" typically associated with pathogenesis.