Genomic Epidemiology of Complex, Multispecies, Plasmid-Borne bla KPC Carbapenemase in Enterobacterales in the United Kingdom from 2009 to 2014

著者: Nicole Stoesser, Hang Phan, Anna C. Seale, Zoie Aiken, Stephanie Thomas, Matthew Smith, David Wyllie, Ryan George, Robert Sebra, Amy J. Mathers, Alison Vaughan, Tim Peto, Matthew J. Ellington, Katie L. Hopkins, Derrick W. Crook, Alex Orlek, William Welfare, Julie Cawthorne, Cheryl Lenney, Andrew Dodgson, Neil Woodford, A. Sarah Walker, the TRACE Investigators’ Group, Zoie Aiken, Oluwafemi Akinremi, Aiysha Ali, Julie Cawthorne, Paul Cleary, Derrick W. Crook, Valérie Decraene, Andrew Dodgson, Michel Doumith, Matthew J. Ellington, Ryan George, John Grimshaw, Malcolm Guiver, Robert L. Hill, Katie L. Hopkins, Rachel Jones, Cheryl Lenney, Amy J. Mathers, Ashley McEwan, Ginny Moore, Mark Neilson, Sarah Neilson, Tim Peto, Hang T. T. Phan, Mark Regan, Anna C. Seale, Nicole Stoesser, Jay Turner-Gardner, Vicky Watts, A. Sarah Walker, Jimmy Walker, David Wyllie, William Welfare, Neil Woodford - Antimicrobial Agents and Chemotherapy 2020 被引用: 47

Carbapenem resistance in Enterobacterales is a public health threat. Klebsiella pneumoniae carbapenemase (encoded by alleles of the bla KPC family) is one of the most common transmissible carbapenem resistance mechanisms worldwide. The dissemination of bla KPC historically has been associated with distinct K. pneumoniae lineages (clonal group 258 [CG258]), a particular plasmid family (pKpQIL), and a composite transposon (Tn 4401 ).