Antiviral and Anti-Inflammatory Effects of Rosmarinic Acid in an Experimental Murine Model of Japanese Encephalitis

著者: Vivek Swarup, Joydeep Ghosh, Soumya Ghosh, Amit Saxena, Anirban Basu - Antimicrobial Agents and Chemotherapy 2007 被引用: 257

Rosmarinic acid (RA) reduced the mortality of mice infected with Japanese encephalitis virus (JEV). Significant decreases in viral loads (P < 0.001) and proinflammatory cytokine levels (P < 0.001) were observed in JEV-infected animals treated with RA compared to levels in infected mice without treatment, at 8 to 9 days postinfection.