Pseudo-anaphylaxis to Polyethylene Glycol (PEG)-Coated Liposomes: Roles of Anti-PEG IgM and Complement Activation in a Porcine Model of Human Infusion Reactions

著者: Gergely Tibor Kozma, Tamás Mészáros, Ildikó Vashegyi, Tamás Fülöp, Erik Őrfi, László Dézsi, László Rosivall, Yaelle Bavli, Rudolf Urbanics, Tom Eirik Mollnes, Yechezkel Barenholz, János Szebeni - ACS Nano 2019 被引用: 210

the classical pathway, entailing anaphylactoid shock and accelerated blood clearance of liposome-IgM complexes. These data suggest that complement activation plays a causal role in severe HSRs to PEGylated nanomedicines and that pigs can be used as a hazard identification model to assess the risk of HSRs in preclinical safety studies.