Mechanical power thresholds during mechanical ventilation: An experimental study

著者: Federica Romitti, Mattia Busana, Maria Michela Palumbo, Matteo Bonifazi, Lorenzo Giosa, Francesco Vassalli, Alessandro Gatta, Francesca Collino, Irene Steinberg, Simone Gattarello, Stefano Lazzari, Paola Palermo, Ahmed Nasr, Ann‐Kathrin Gersmann, Annika Richter, Peter Herrmann, Onnen Moerer, Leif Saager, Luigi Camporota, John J. Marini, Michael Quintel, Konrad Meissner, Luciano Gattinoni - Physiological Reports 2022 被引用: 45

were worse compared to 7 J and 12 J groups (all p < 0.001), due to lower ventilation-perfusion ratio (0.54 ± 0.13, 1.00 ± 0.25, 1.78 ± 0.36 respectively, p < 0.001). The lung weight was lower (p < 0.001) in the controls (6.56 ± 0.90 g/kg) compared to 3, 7, and 12 J groups (12.9 ± 3.0, 16.5 ± 2.9, and 15.0 ± 4.1 g/kg, respectively). The wet-to-dry ratio was 5.38 ± 0.26 in controls, 5.73 ± 0.52 in 3 J, 5.99 ± 0.38 in 7 J, and 6.13 ± 0.59 in 12 J group (p = 0.03). Vascular congestion was more extensive in the 7 J and 12 J compared to 3 J and control groups. Mechanical ventilation (with anesthesia/paralysis) increase lung weight, and worsen lung histology, regardless of the mechanical power. Ventilating at 3 J/min led to better anatomical variables than at 7 and 12 J/min but worsened the physiological values.