Evolution of Cefiderocol Non-Susceptibility inPseudomonas aeruginosain a Patient Without Previous Exposure to the Antibiotic

著者: Ana Paula Streling, Mohanad M. Al Obaidi, William Lainhart, Tirdad T. Zangeneh, Ayesha Khan, An Q Dinh, Blake Hanson, César A. Arias, William R. Miller - Clinical Infectious Diseases 2021 被引用: 74

We report the emergence of non-susceptibility to cefiderocol from a subpopulation of Pseudomonas aeruginosa recovered from a patient without history of cefiderocol exposure. Whole genome sequencing identified mutations in major iron transport pathways previously associated with cefiderocol uptake. Susceptibility testing should be performed before therapy with siderophore cephalosporins.