Shared transcriptional profiles of atypical B cells suggest common drivers of expansion and function in malaria, HIV, and autoimmunity

著者: Prasida Holla, Brian Dizon, Abhijit A. Ambegaonkar, Noga Rogel, Ella Goldschmidt, Arun K. Boddapati, Haewon Sohn, Dan E. Sturdevant, James W. Austin, Lela Kardava, Yuesheng Li, Poching Liu, Susan Moir, Susan K. Pierce, Asaf Madi - Science Advances 2021 被引用: 159

ABCs acquired a high antigen affinity threshold for activation, suggesting that ABCs may limit autoimmune responses to low-affinity self-antigens in chronic malaria.