GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

著者: Alexessander Couto Alves, N. Maneka G. De Silva, Ville Karhunen, Ulla Sovio, Shikta Das, H. Rob Taal, Nicole M. Warrington, Alex Lewin, Marika Kaakinen, Diana L. Cousminer, Elisabeth Thiering, Nicholas J. Timpson, Tom A. Bond, Estelle Lowry, Christopher D. Brown, Xavier Estivill, Virpi Lindi, Jonathan P. Bradfield, Frank Geller, Doug Speed, Lachlan Coin, Marie Loh, Sheila J. Barton, Lawrence J. Beilin, Hans Bisgaard, Klaus Bønnelykke, Rohia Alili, Ida J. Hatoum, Katharina Schramm, Rufus Cartwright, Marie‐Aline Charles, Vincenzo Salerno, Karine Clément, Annique Claringbould, Cornelia M. van Duijn, Elena Moltchanova, Johan G. Eriksson, Cathy E. Elks, Bjarke Feenstra, Claudia Flexeder, Stephen Franks, Timothy M. Frayling, Rachel M. Freathy, Paul Elliott, Elisabeth Widén, Håkon Håkonarson, Andrew T. Hattersley, Alina Rodriguez, Marco Banterle, Joachim Heinrich, Barbara Heude, John W. Holloway, Albert Hofman, Elina Hyppönen, Hazel Inskip, Lee M. Kaplan, Åsa K. Hedman, Esa Läärä, Holger Prokisch, Harald Grallert, Timo A. Lakka, Debbie A. Lawlor, Mads Melbye, Tarunveer S. Ahluwalia, M. Marinelli, Iona Y. Millwood, Lyle J. Palmer, Craig E. Pennell, John R. B. Perry, Susan M. Ring, Markku J. Savolainen, Fernando Rivadeneira, Marie Standl, Jordi Sunyer, Carla M. T. Tiesler, André G. Uitterlinden, William Schierding, Justin M. O’Sullivan, Inga Prokopenko, Karl‐Heinz Herzig, George Davey Smith, Paul F. O’Reilly, Janine F. Felix, Jessica L. Buxton, Alexandra I. F. Blakemore, Ken K. Ong, Vincent W. V. Jaddoe, Struan F.A. Grant, Sylvain Sebért, Mark I. McCarthy, Marjo‐Riitta Järvelin - Science Advances 2019 被引用: 164

locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.