The cumulative burden of double-stranded DNA virus detection after allogeneic HCT is associated with increased mortality

著者: Joshua A. Hill, Bryan T. Mayer, Hu Xie, Wendy M. Leisenring, Meei‐Li Huang, Terry Stevens‐Ayers, Filippo Milano, Colleen Delaney, Mohamed L. Sorror, Brenda M. Sandmaier, Garrett Nichols, Danielle M. Zerr, Keith R. Jerome, Joshua T. Schiffer, Michael Boeckh - Blood 2017 被引用: 173

= .054). The maximum cumulative viral load AUC was the best predictor of early (days 0-100) and late (days 101-365) overall mortality (adjusted hazard ratio [aHR] = 1.36, 95% confidence interval [CI] [1.25, 1.49], and aHR = 1.04, 95% CI [1.0, 1.08], respectively) after accounting for immune reconstitution and graft-versus-host disease. In conclusion, detection of multiple dsDNA viruses was frequent after allogeneic HCT and had a dose-dependent association with increased mortality. These data suggest opportunities to improve outcomes with better antiviral strategies.