Targeted Deletion of the Ileal Bile Acid Transporter Eliminates Enterohepatic Cycling of Bile Acids in Mice
The ileal apical sodium bile acid cotransporter participates in the enterohepatic circulation of bile acids. In patients with primary bile acid malabsorption, mutations in the ileal bile acid transporter gene (Slc10a2) lead to congenital diarrhea, steatorrhea, and reduced plasma cholesterol levels. To elucidate the quantitative role of Slc10a2 in intestinal bile acid absorption, the Slc10a2 gene was disrupted by homologous recombination in mice. Animals heterozygous (Slc10a2 + / –) and homozygous (Slc10a2 / –) mice. In the Slc10a2 / bile acid was to and was by bile acid bile acid the bile acid was by and in acid in the Slc10a2 / mice. the Slc10a2 / was and intestinal cholesterol was reduced the bile acid was to intestinal was reduced by in Slc10a2 / and plasma cholesterol Slc10a2 intestinal of bile and to of Slc10a2 The ileal apical sodium bile acid cotransporter participates in the enterohepatic circulation of bile acids. In patients with primary bile acid malabsorption, mutations in the ileal bile acid transporter gene (Slc10a2) lead to congenital diarrhea, steatorrhea, and reduced plasma cholesterol levels. To elucidate the quantitative role of Slc10a2 in intestinal bile acid absorption, the Slc10a2 gene was disrupted by homologous recombination in mice. Animals heterozygous (Slc10a2 + / –) and homozygous (Slc10a2 / –) mice. 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