NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury

著者: Jia Zhou, Yang Geng, Tonghui Su, Qiuyan Wang, Yongfei Ren, Jing Zhao, Chaoying Fu, Martin Weber, Han Lin, Joshua S. Kaminker, Nan Liu, Morgan Sheng, Yelin Chen - Cell Reports 2022 被引用: 18

). NMDAR inhibition or Ptgs2 genetic ablation in mice reduced the proliferation of astrocytes and microglia induced by mild traumatic brain injury in the absence of secondary excitotoxicity-induced neuronal death. Our study defines an NMDAR-mediated signaling mechanism that allows trans-cellular control of glial proliferation by neurons in brain development and injury.