Neutrophil cytoplasts induce T H 17 differentiation and skew inflammation toward neutrophilia in severe asthma

著者: Nandini Krishnamoorthy, David N. Douda, Thayse R. Brüggemann, Isabell Ricklefs, Melody G. Duvall, Raja-Elie E. Abdulnour, Kimberly Martinod, Luciana P. Tavares, Xiao Wang, Manuela Cernadas, Elliot Israel, David T. Mauger, Eugene R. Bleecker, Mario Castro, Serpil C. Erzurum, Benjamin Gaston, Nizar N. Jarjour, Sally E. Wenzel, Eleanor M. Dunican, John V. Fahy, Daniel Irimia, Denisa D. Wagner, Bruce D. Levy - Science Immunology 2018 被引用: 238

T cells. Bronchoalveolar lavage fluid from patients with severe asthma and high neutrophil counts had detectable NETs and cytoplasts that were positively correlated with IL-17 levels. Together, these translational findings have identified neutrophil cytoplast formation in asthmatic lung inflammation and linked the cytoplasts to T helper 17-mediated neutrophilic inflammation in severe asthma.