Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial

著者: Michael D. Hill, Mayank Goyal, Bijoy K. Menon, Raul G. Nogueira, Ryan McTaggart, Andrew M. Demchuk, Alexandre Y. Poppe, Brian Buck, Thalia S. Field, Dar Dowlatshahi, Brian van Adel, Richard H. Swartz, Ruchir Shah, Eric Sauvageau, Charlotte Zerna, Johanna M. Ospel, Manish Joshi, Mohammed Almekhlafi, Karla J. Ryckborst, Mark Lowerison, Kathy Heard, David Garman, Diogo C Haussen, Shawna M Cutting, Shelagh B. Coutts, Daniel Roy, Jeremy Rempel, Axel Rohr, Daniela Iancu, Demetrios J. Sahlas, Amy Yu, Thomas Devlin, Ricardó A. Hanel, Volker Puetz, Frank L. Silver, Bruce Campbell, René Chapot, Jeanne Teitelbaum, Jennifer Mandzia, Timothy Kleinig, David Turkel‐Parrella, Donald Heck, Michael Kelly, Aditya Bharatha, Oh Young Bang, Ashutosh P. Jadhav, Rishi Gupta, Donald Frei, Jason Tarpley, Cameron McDougall, Staffan Holmin, Joung‐Ho Rha, Ajit S Puri, Marie‐Christine Camden, Götz Thomalla, Hana Choe, Stephen Phillips, Joseph Schindler, John Thornton, Simon Nagel, Ji Hoe Heo, Sung‐Il Sohn, Marios‐Nikos Psychogios, Ronald F. Budzik, Sidney Starkman, Coleman Martin, Paul Burns, Séan Murphy, George Α. Lopez, Joey English, Michael Tymianski, Andrew M. Demchuk, Philip A. Barber, Eric E. Smith, Simerpreet Bal, Suresh Subramaniam, Steven Peters, P Couillard, Gary Klein, Peter K. Stys, Bijoy K. Menon, Shelagh B. Coutts, Mohammed Almekhlafi, Michael D. Hill, Mayank Goyal, John Wong, Alim P. Mitha, Muneer Eesa, William Morrish, Saad Alqatani, Nima Kashani, Manish Joshi, Charlotte Zerna, Johanna M. Ospel, Prasanna Venkatesan, Erika Teleg, Amith Sitaram, Brett Graham, Stephen van Gaal, Aimen Moussaddy, Debabrata Chakraborty, Nicholas Maraj, Andrew Loockey, Shuo Chen, Ravinder Singh, Abdulaziz S. Al Sultan, R.M. Asuncion, Dominic Tse, Darshan Doshi, Ondřej Volný, Piyush Ojha, Ankur Wadhwa, Martha Marko, Nishita Singh, Sanchea Wasyliw, Karla J. Ryckborst, Carol Kenney, Supriya Save, Anitha Jambula, Nancy Newcommon, G Hull, Darcy Blackstock, Sharon Kiszczak, L Zimmel, Michelle Wright, Cari Jahraus, Linda Andersen, Shelly Bohn, Joseph Paul, Oiao Zhang, Craig Doram, Mark Lowerison, Andrea Hanley, Lori Campbell, Ashley Ure, F W Taylor, Dominic Hul, Samuel Wiebe, Marina Saluzzi, Nicole Blenkin, Richard Frayne, Brian Buck, Kenneth Butcher, Ashfaq Shuaib, Tom Jeerakathil, Glen C. Jickling, Derek Emery, Jeremy Rempel, Richard Owen, Robert Ashforth, Tom Yeo, Trevor Kotylak, Cian O′Kelly, Michael Chow, Muzaffer Siddiqui, Maher Saqqur, Atlantic D’Souza, Mar Lloret, Asif Butt, Ali Zohair Nomani, Hayrapet Kalashyan, Sibi Thirunavukkarasu, Juline Jabs, Paige Fairall, Lori Piquette, Stephen Phillips, A. Laine Green, Gordon Gubitz, Jens O. Heidenreich, Thien Huynh, Jai Shankar, William J. Maloney, Robert Vandorpe, Matthias H. Schmidt, Gwynedd E. Pickett, Adrienne Weeks, J Jarrett, Debbie MacDonald, Joanna Arsenault, Ruth Kinnear, Jennifer Mandzia, Michael Mayich, Melfort Boulton, María Bres Bullrich, Sebastián Fridman, Ruba Kiwan, Donald Lee, Stephen Lownie, Alexander V. Khaw, Sachin Pandey, Manas Sharma, Luciano A. Sposato, Kevin Wade, Beth Beauchamp, Lindsay Lambourn, Belinda Amato-Marziali, Alexandre Y. Poppe, Daniel Roy, Nicole Daneault, Yan Deschaintre, Laura Gioia, Grégory Jacquin, Céline Odier, Christian Stapf, Daniela Iancu, Jean Raymond, Alain Weill, Marlène Lapierre, Nadia Jadil, Judlène Jolteus, Jeanne Teitelbaum, Mark Angle, Mathew Hannouche, Mohamed Badawy, Justin Létourneau, Maria Cortes, Grant Linnell, Donateela Tampieri, Lucy Vieira, Aimen Moussaddy, Catherine Legault, Liam Durcan, Angela Moore, Erin L. Cole, Claire Magnussen, Kristiana Salmon, Salma Khalil, Isabelle Desloges, Lindsay Waxman, Wynne Abdon, Sonia Lai, Dar Dowlatshahi, Daniela Iancu, Michel Shamy, Grant Stotts, Dylan Blacquière, Howard Lesiuk, Aiman Quateen, Brian Drake, Brian Dewar, Zeinab Daham, Michael Kelly, Gary Hunter, Lissa Peeling, Brett Graham, Ruth Whelan, Aaron Garner, Lilian Urroz, Sharleen Maley, Frank L. Silver, Leanne K. Casaubon, Aleksandra Pikula, Martín del Campo, Joanna D. Schaafsma, Cheryl Jaigobin, Timo Krings, Vítor Mendes Pereira, Ronit Agid, Richard Farb, Libby Kalman, Anne Cayley, Janice E. Williams, Tim Stewart, Karen Misquitta, Aditya Bharatha, Daniel Selchen, Thomas R. Marotta, Dipanka Sarma, Walter Montanera, Juluan Spears, Gustavo Saposnik, Pawel Kostyrko, Yangmei Li, Carmen Parra-Farina, Jose Danilo Bengzon Diestro, Marie‐Christine Camden, Steve Verreault, Ariane Mackey, Marie‐Ève Audet, Geneviève Milot, Pascale Lavoie, Jean‐Luc Gariépy, Karine Collard, Annette Haché, Brian van Adel, Demetrios J. Sahlas, Ahmed M. Alshanbari, Josephine Baldwin, Luciana Catanese, Bing Chen, Danielle de Sá Boasquevisque, Aviraj Deshmukh, Jordan Knapman, Shana Lamers, Ramiro Larrazabal, Susan Macmillan, Lauren Mai, Alicia Mattia, Sumiti Nayar, Kuan H. Ng, Wieslaw Oczkowski, Kanjana Perera, Mays Shawawrah, Ashkan Shoamanesh, Gita Sobhi, Nabeel Muzaffar Syed, Noran Taher, Cheyanne Vandervelde, D Pharm, Thalia S. Field, Stephen van Gaal, Philip Teal, Oscar Benavente, Laura Wilson, Sharanpal Mann, Samuel Yip, Colleen Murphy, Manraj K. S. Heran, Axel Rohr, Fabio Settecase, Gary Redekop, Charles S. Haw, Genoveva Maclean, Karina Murray, Rosalin Chiu, Alana M. Flexman, Eilidh Strecha, Yolanda Gayton, Judy Yip, Richard H. Swartz, Mark I. Boulos, David J. Gladstone, Amy Yu, Julia Hopyan, Houman Khosravani, Herbert Manosalva Alzate, Alisia Southwell, Maneesha Kamra, Kaitlyn Lopes, Arunima Kapoor, Leodante da Costa, Victor X. D. Yang, Erin Dyer, Ruchir Shah, Brenda Knowles, Jennifer Nichols, Jennifer Patterson, Krista A. Cope, Lee Dickerson, Katrina Barton, Kimberly Gray, Ticey N. Massengale, Melanie M. Miller, Cindy Simpson, Sabrina Walker, Chlin R. Tennyson-Yemm, Thomas Devlin, Donald Frei, Richard Bellon, Benjamin Atchie, Ian Kaminsky, Duandelyn C. Wilson, Nicolle L. Schraeder, Eric Arias, Lisa M. Kodis, Mark E. Talley, Alex A. Edinger, Tiffany Talley, Ita P. Dempsey, Laurie Williams, Scott A. Williams, Sonny Kupniewski, Brad K. Fasbinder, Joanna M. Snead, Hana Choe, Larami Mackenzie, D. Weisman, Osman Kozak, Qaisar A. Shah, Dan Gzesh, Kandan Kulandaivel, John Khoury, Brad Klein, Patricia Bussinger, Lisa Griffin, Ashley L. 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Emmady, Talat Alvi, Ryan McTaggart, Mahesh Jayaraman, Shawna Cutting, Wendy Smith, Susan M. Foley, G Paolucci, Richard Has, Katie Quinn, Lindsey Fuller, Rebecca E. Brierley, Christina C. Watkins, Nicole C. Demir, George Α. Lopez, Alejandro Vargas, Nicholas Osteraas, Becky Holtz, Eric Sauvageau, Ricardó A. Hanel, Amin Aghaebrahim, Mohamad Chmayssani, Neeraj S. Naval, Jason S. Day, Scott Dellorso, Benjamin J. Ludwig, Derek J. Schemmel, Nancy Ebreo, Karen Bell, Lanai Lewis, Marjorie Delucia, Raul G. Nogueira, Diogo C Haussen, Michael Frankel, Nirav Bhatt, Nicolas Bianchi, Aaron Anderson, Samir Belagaje, Bernardo Liberato, Srikant Rangaraju, Alhamza R Al‐Bayati, Jonathan A Grossberg, Leah Craft, Kiva Schindler, Erin Schaad, Meagan Schultz, Lorretta Southerly, Shannon Doppelheuer, Jacquelyn Charlton, Jason Faggard, Zuzana Barbret, Ethan DukSoo Han, Robin Walters, Jaydevsinh Dolia, Sleiman El-Jamal, Brendan Eby, Yasir Saleem, Harrison Pearl, Kishan Patel, Haseeb Rahman, Reema Butt, Stephen English, Ajit S Puri, M Howk, Jasmeet Singh, Francesco Massari, Katyucia DeMacedo Rodrigues, Anna Luisa Kühn, Joey English, Nobl Barazangi, Nick Telischak, Warren Kim, Josh Ross, Nata DeVole, Jessica Redford, Milena Ferreira, Katie Ponting, Helen Shen, Ann Bedenk, Susila Patel, Julia Fernandess, Michael Ke, Ilanit Spokoyny, Billy Gao, David Tong, Xiaomeng Chen, Christine Wong, Jessica Choe, Coleman Martin, Debbie Summers, Christine Boutwell, Karin Olds, Suzanne Crandall, John Eatman, Naveed Akhtar, W Holloway, J Halpin, Brett Donegan, Joseph Schindler, David Y. Hwang, Emily J. Gilmore, Nils Petersen, Kevin N. Sheth, Stacy Brown, Rachel Beekman, Benjamin P. George, Firas Kaddouh, Guido J. Falcone, Charles Wira, Charles Matouk, Caitlin Loomis, Hardik Amin, Hans Christoph Stretz, Reshma Narula, Adam Jasne, Lauren Sansing, Tijil Agarwal, Sara Jasak, Dominique Fontaine, Zachary A. King, Lindsey Kuohn, Hailey Orgass, Megan Leary, Joan Nye, Kelsey Halbert, Karin Nyström, Kaile Neuschatz, Dawn M. Petrucci, Anna Coppola, Jason Tarpley, Treasure A. Joyce, Sam Hou, Mark S. Umekubo, Catrice M. Nakamura, Renee Ovando, Diana Zúñiga, Yih Lin Nien, Fernando Mayor Basto, Allison E. Arch, Laura W. de Jong, William A. Conrad, Tara C. Abbott, Jay Z. Yao, Scott D. Caganap, John E. Jordan, George P. Teitelbaum, Robert Darflinger, Rishi Gupta, Marianne Bain, Ronald F. Budzik, Jennifer H. Czerniak, Katherine M. Groezinger, William J. 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Jackson, Jessica Tsoleridis, Lauren Pesavento, Timothy Kleinig, Roy Drew Nurs, Jennifer Cranefield, Rebecca Scroop, Lavenia Cagi, Jackson Harvey, Michael F. Waters, John Thornton, Robert T. Brennan, Alan O’Hare, Sarah Power, David Williams, Karl Boyle, Barry Moynihan, Ann-Marie Liddy, Margaret Large, Ailbhe Cullen, Roisin Walsh, Emma Martin, Julie Lynch, Sinéad McElroy, Séan Murphy, Sarah Coveney, Caroline Deegan, Gillian Horgan, Peter J. Kelly, Aoife Laffan, Yudy Llamas-Osorio, Catherine Lynch, Peter Mac Mahon, Michael Marnane, John McCabe, Paul Burns, Suzanne Tauro, Sarah Cuddy, Ian Rennie, Graham Smyth, Peter Flynn, Ivan Wiggam, Enda Kerr, Patricia Gordon, Patricia Fearon, Geralt Roberts, Cathy Patterson, Karen E. Adams, Brian Wells, Margaret McFarland, Staffan Holmin, Tiago Moreira, Christina Sjöstrand, Michael V. Mazya, Håkan Almqvist, Nils Wahlgren, Anna Steinberg, Charith Cooray, Einar E. Eriksson, M. Thorén, Boris Keselman, Niaz Ahmed, Åke Holmberg, Maria Axelsson, Annika Berglund, Götz Thomalla, Amir Golsari, Julia Hoppe, Milani Deb‐Chatterji, Bastian Cheng, E Barrow, Eckhard Schlemm, Iris Lettow, Märit Jensen, Dagmar Otto, Kirsten Jaramillo, Hannes Appelbohm, Jens Fiehler, Maxim Bester, Michael Schönfeld, Caspar Brekenfeld, Brigitte Holst, Ginette Wortmann, Friederike Koch, Volker Puetz, Johannes Gerber, Andrij Abramyuk, Daniel Kaiser, Simon Winzer, Alexandra Prakapenia, Lars‐Peder Pallesen, Timo Siepmann, Kristian Barlinn, Kathrin Haase, Angela Sauer, Marios‐Nikos Psychogios, Jan Liman, Alex Brehm, Volker Maus, Nicole Hollstein, Annika Reinke, Gustav Neitz, Marlena Schnieder, Margret Schwarz, Allam Ibrahim, Julia Müller, Stefanie Meister, Berit Bäumle, René Chapot, Sara Pilgram‐Pastor, Marta Wallocha, Michael C. Stauder, Ekin Celik, Paul Stracke, Nicole Müller, Ralph Weber, Roland Velktamp, Simon Nagel, Peter A. Ringleb, Miriam Heyse, Hemasse Amiri, Sibu Mundiyanapurath, Min Chen, Elisabeth Bevrle, Perdita Beck, Markus Möhlenbruch, Michael Tymianski, Alphonse R.J. Potvin, Cameron Harris, Chong Wang, Corey Adams, Diana Mayor, D. Melissa Garman, Davis Chau, Jane Wu, Janet Lunn, Kathy Heard, Liat Bermanis, Lucy Teyes, Marc Constant, Maria Galsim, Michael Helbin, Michelle Leroux, Nicole Felix, Nilima Bendre, Sandra Cuthbert, Steve Brokx, Yichuan Zhang, Trudy Lingham, Yatika Kohli, Michael W. Salter, Joseph Liebeschuetz, Frieder Hofmann, John Constant, Tom Soeder, Kara Snoke, Monica Bologa, Kimberly Stahl, Maria A Graziewicz - The Lancet 2020 被引用: 629