Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Cobalt Pincer Complex

著者: Arup Mukherjee, Dipankar Srimani, Subrata Chakraborty, Yehoshoa Ben‐David, David Milstein - Journal of the American Chemical Society 2015 被引用: 285

The catalytic hydrogenation of nitriles to primary amines represents an atom-efficient and environmentally benign reduction methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts, with a single exception. Here we report the first homogeneous Co-catalyzed hydrogenation of nitriles to primary amines. Several (hetero)aromatic, benzylic, and aliphatic nitriles undergo hydrogenation to the corresponding primary amines in good to excellent yields under the reaction conditions.