Cyclophosphamide in Lupus Nephritis: A Controlled Trial

著者: Alfred D. Steinberg, H. BENFER KALTREIDER, PARKER J. STAPLES, EDWARD J. GOETZL, NORMAN TALAL, JOHN L. DECKER - Annals of Internal Medicine 1971 被引用: 209

Thirteen women with lupus nephritis were hospitalized for a 10-week double-blind therapeutic trial comparing oral cyclophosphamide with placebo. Concurrent corticosteroid therapy, up to 30 mg/day of prednisone, was permitted. Patients receiving cyclophosphamide had greater improvement than did placebo-treated patients in five indexes: anti-DNA antibodies, serum complement, urine sediment, proteinuria, and extrarenal disease. There was no difference in creatinine clearance. There was a strong positive correlation between cyclophosphamide dosage and number of indexes improved. Toxic side effects of cyclophosphamide were noted.