Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions

著者: Shengjun Wang, Yang Mao, Yoshiki Narimatsu, Zilu Ye, Weihua Tian, Christoffer K. Goth, Erandi Lira‐Navarrete, Nis Borbye‐Lorenzen, Asier Benito‐Vicente, César Martı́n, Kepa B. Uribe, Ramón Hurtado‐Guerrero, Christina Christoffersen, Nabil G. Seidah, Rikke Nielsen, Erik Christensen, Lars Hestbjerg Hansen, Eric Bennett, Sergey Y. Vakhrushev, Katrine T. Schjoldager, Henrik Clausen - Journal of Biological Chemistry 2018 被引用: 82

-glycosylation increased affinity for LDL by ∼5-fold. The molecular basis for this observation is currently unknown, but these findings open up new avenues for exploring the roles of LDLR-related proteins in disease.