Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

著者: RECOVERY Collaborative Group, Peter Sandercock, Janet Darbyshire, David L. DeMets, Robert Fowler, David G. Lalloo, Mohammed Munavvar, Adilia Warris, Janet Wittes, Central Coordinating Office (for the RECOVERY Collaborative Group), Andrea Cradduck-Bamford, Jill Barton, Ahmet Başoğlu, R. Brown, Wojciech Brudlo, É. Denis, Lucy Fletcher, Sarah Howard, K. Taylor, Guanglin Cui, Belinda Goodenough, Alexander H. King, M Lay, David W. Murray, William Stevens, Karl Wallendszus, R. Wels, Charles Crichton, J. Davies, Raph Goldacre, Charlie Harper, F. I. KNIGHT, Miles A. Nunn, Hizni Salih, John J. Welch, Mohamed A. Zayed, Jonathan D. Wiles, GRANT P. BAGLEY, Scott J. Cameron, Samuel R. Chamberlain, Barbara Farrell, Hannah Freeman, Ann R. Kennedy, Anne Whitehouse, S. Wilkinson, C Wood, Christina Reith, Katherine Davies, Heather Halls, Lisa Holland, Rory Truell, Ken Wilson, L Howie, Michael P. Lunn, Philip T. Rodgers, Louise Bowman, Fang Chen, Robert Clarke, Michelle Goonasekara, William G. Herrington, P. G. Judge, S. Ng, D. Preiss, Emily Sammons, Doreen Zhu, Amanda Barnard, J Beety, Chris Birch, Morwenna Brend, Emma S. Chambers, Lucy C. Chappell, Sarah Crawshaw, Charles G. Drake, Hayley Duckles-Leech, James E. Graham, T Harman, H. Harper, S Lock, Kaatje Lomme, Nigel A.J. McMillan, Ian Nickson, Udeme Ohia, Eleanor OKell, Vanessa Poustie, Soya S. Sam, Peter J. Sharratt, John Sheffield, Herbert B. Slade, William van’t Hoff, Samantha Walker, James D Williamson, Anthony De Soyza, Paul Dimitri, Saul N. Faust, Nicholas R. Lemoine, Jane Minton, Kimberly Gilmour, Karen Pearson, Charlotte Armah, Danielle Campbell, Hugo Ten Cate, Andrew N. Priest, E Thomas, R. Usher, Graham Johnson, M Logan, Steven Pratt, Anna Price, K. A. Shirley, E Walton, Petal Petersen Williams, F. Yelnoorkar, Jane Hanson, Helen Membrey, Liz Gill, Antonio Oliver, Swati Das, Simon Murphy, Mihaela Sutu, Joanne Collins, H. Monaghan, A. Unsworth, Simon Beddows, Kerry Barker-Williams, Shawn Dowling, Kristen Gibbons, Kathleen H. Pine, A. Asghar, Paula Aubrey, Dawn Beaumont-Jewell, K Donaldson, Timothy Skinner, Ji Luo, Nhlanhla Mguni, Natasha Muzengi, Richard J. Pleass, Emma Wayman, Anna‐Britt Coe, James W. Hicks, Michael Hough, Chris Levett, Alexandra L. Potter, Julie Taylor, Mary Dolman, Lee Gerdes, Claire Hall, T. Lockett, David A. Porter, John R. Bartholomew, Lucy Dowden, C Rook, James B. Walters, Erika Denton, Heather Tinkler, Adam C. Alexander, Helen Campbell, K Chapman, Anthony J. Hall, Anthony Rodgers, Peter Boyle, Matthew Brookes, Claire Callens, Helen Duffy, Cameron Green, Kate Hampshire, Stephanie L. Harrison, Jeremy Kirk, Misbah Naz, Linda Porter, Pablo Ryan, Jacintha Shenton, John R. Warmington, M. R. Amezaga, Pamela Dicks, Joanne Goodwin, Helen Hodgson, SL Jackson, Miranda Odam, D. Williamson, Health records (for the RECOVERY Collaborative Group), Heather Pinches, P. Bowker, Victoria Byrne-Watts, G Chapman, Glen Coleman, J.D. Gray, Andrew Rees, Nancy Mather, Tom Denwood, David A Harrison, Grace Turner, Johanna Bruce, C Arkley, Sarah Rees, J Alin, L Anguvaa, Joseph Bae, Gabriela Bega, Simon Bowman, Arup Chakraborty, Elizabeth L. Clare, Simon W. Fox, Samantha Franklin, Sarah L. George, Lee How, Marcus P. Kennedy, Judy Mead, Louise Mew, Dushyant Mital, Lisa Moran, Esther Mwaura, Mala Nathvani, Alastair Rose, Diane Scaletta, S. Shah, Loria Siamia, Oliver Spring, Stephanie Sutherland, François Teasdale, Sameer Velankar, L. Wren, Francesca Wright, M Abouzaid, Christopher Adams, Ahmad Al Aaraj, Osama Alhabsha, Mohammad Ali, E Aliberti, Dennis W. Ashley, Daniel Barker, Humayun Bashir, Bridget Campbell, A Chilvers, E Chinonso, Victoria Collins, E Connell, Kevin Conroy, Eline G. M. Cox, Jennifer Deane, J Dunleavy, Isabelle Fenner, Chun Loo Gan, Isha Garg, Catherine Gibb, Sharon Gowans, William Hartrey, Félix Manuel Francisco Hernández, Joseph Jacob, Vidhya Jagannathan, Vandana Jeebun, Sandra Jones, Michael Khan, Yuan Jun Koe, D Leitch, Lessica M Magnaye, Trupti Mane, T Mazhani, Nolan McDonnell, Mohamed Nafei, Becky Baltich Nelson, L. Poole, Elizabeth Poyner, Scott F. Purvis, J Quigley, Alex Ramshaw, Harmony R. Reynolds, Lisa A. Robinson, Ian Louis Ross, R Salmon, Lois E. Shepherd, Elaine Siddle, S Sinclair, Matthew Smith, R. Sathish Srinivasan, Kirsten Stewart, Rachel A. Taylor, Graham R. Wallace, Shuang Wang, Lea C. Watson, Maria Weetman, Bill Wetherill, Sarah H. Wild, K. Win, Timothy Felton, Simon Carley, Robert Lord, Andrew Ustianowski, Mustafa Abbas, Aqsa Rasheed, Thomas Abraham, Sandeep Aggarwal, Asim A. Ahmed, Suha Akili, Paul Alexander, Alison Allanson, B Al-Sheklly, Deepak Arora, Miriam Avery, Cristina Avram, A. Aya, Juan M. Banda, Helen Banks, Mireille Baptist, Manuel Barrera, E Barrow, Raveen Bazaz, Roya Behrouzi, Miriam Bennett, Victoria S. Benson, Andrew Bentley, Arjun Bhadi, A. Biju, András Bikov, K Birchall, Sujata Blane, Syed Akhtar Hussain Bokhari, Paul Bradley, Joanne Bradley-Potts, John Bright, R. Brown, Stephen Burgess, Muhammad Hammad Butt, G Calisti, Charles Carey, Nazia Chaudhuri, S. Chilcott, Catherine Chmiel, A Chrisopoulou, Elaine Church, Richard Clark, Jill Clayton‐Smith, Richard Conway, Eloïse Cook, SS Crasta, Gillian Cummings-Fosong, Sue Currie, Hannah Dalgleish, Cheryl Davies, Kristen Dean, Amisha Desai, Rami Dhillon, Jayne Digby, D. H. Dolan, Gary Donohoe, Annette Duggan, Bülent Duran, Hannah Durrington, Chris Eades, Ruth Eatough, Sarah Elyoussfi, Fadl A. Essa, D. Gareth Evans, Andy Fairclough, David Faluyi, S. Ferguson, J W L Fielding, Sofia Fiouni, Jan Flaherty, Gerard J. Fogarty, Stephen J. Fowler, Amy S. Fox, Julie Fox, B George, V George, Sarra Giannopoulou, Robert Gillott, Adrianna Gipson, Simon Glasgow, T Gorsuch, Generosa Grana, Gregory C. Gray, A. Grayson, Glaxy Grey, Brian P. Griffin, Jean‐Luc Guérin, Pamela Hackney, Bilal Hameed, Iwan Sahrial Hamid, Sarah P. Hammond, Soran Handrean, A Harvey, Jonathan J. Henry, Spencer Phillips Hey, Linda W. Higgins, L Holt, Alex Horsley, Louise M. Howard, Stephen Hughes, Adam Hulme, Peter Hulme, Afreen Hussain, M Hyslop, J Ingham, Omar Ismail, A. Jafar, R Jama, Shakeel Jamal, L. James, F. W. Jennings, Ann John, Maya John, Elaine Johnstone, Dipak Kanabar, Nicholas Karunaratne, Zunaira Kausar, Jossy N Kayappurathu, Ronan J. Kelly, Asad Khan, Wajahat Khan, Jenny King, Sarah Knight, Eirene Kolakaluri, Chris Kosmidis, E. Kothandaraman, Suzanne Krizak, K Kuriakose, Nyan M Kyi, Fiona Lalloo, G Lawrence, Gabriella Lindergard, Caomhán Logue, Laura Macfarlane, A. Madden, Ajit Mahaveer, Lenore Manderson, Georgios Margaritopoulos, Peter V. Marsden, John Mathews, Alexander G. Mathioudakis, Eoghan McCarthy, Jason McDermott, Brendan McGrath, Paddy McMaster, Heather McMullen, C. Mendonca, Aleksandra Metryka, Daniel Micallef, Aseem Mishra, H Mistry, Sandip Mitra, Sarah Moss, Ali Muazzam, Dalia Mudawi, Clare Murray, Mohamed Naguib, S. Naveed, Philip T. Ninan, Mahesh Nirmalan, R Norton, N Odell, Robyn Osborne, Grace Padden, Alberto Palacios, Alice Panes, C. F. A. Pantin, Ben Parker, L Peacock, Alice Peasley, N. Phillips, Myat T T PI, Fiona Pomery, James L. Potts, Nick Power, Molly Pursell, Avinash Ramchandani, A. Rasheed, Sarah J. Ratcliffe, Muredach P. Reilly, Charles Reynard, Emily Rice, M Rice, Phil Riley, P. Rivera Ortega, Jason Rogers, Thomas R. Rogers, R Santosh, T Scoones, Anne Scott, K. C. Sellers, Nesrin Şen, Toni Shanahan, Anna Shawcross, S. Shibly, Cassandra Shilladay, Angela Simpson, Sivanthi Sivanadarajah, Nicole Skehan, C. Smith, John A. Smith, Lauren C. Smith, Jennifer Soren, William Spiller, Kirsten Stewart, Jon Stratton, A. Stubbs, Ajithkumar Sukumaran, Katarzyna Swist-Szulik, Ben Tallon, C Taylor, R Tereszkowski-Kaminski, Samantha Thomas, Sally Thorpe, Mohamed Tohfa, Ruhaif Tousis, Teyfik Turgut, Mathew Varghese, Giulia Varnier, Ian Venables, S. P. Vinay, Ran Wang, Lisa Wård, Christian Warner, Eleanor Watson, Donna Watterson, Lauren Wentworth, Christina Whitehead, Donna M. Wilcock, J. Williams, Erik A. Willis, Louise Woodhead, S. Worton, B. Xavier, Tony Whitehouse, Irshad Ahmed, Nicola Anderson, Courtney Armstrong, Alasdair Bamford, Hollie Bancroft, M. Bates, Michael Bellamy, Terramika Bellamy, Colm Bergin, K Bhandal, Elaine Butler, M. Carmody, Nicole Cianci, Kate Clay, Louise Cooper, Jacqueline Daglish, J Dasgin, A Desai, S. Dhani, Davinder Dosanjh, E Förster, Jo Gresty, Evelina Grobovaite, Najmul Haider, Benjamin S. Hopkins, Diana Hull, Y. Hussain, A. Kailey, M Lacson, Michael R. Lovell, Daniel Lynch, C. A. McGhee, C. McNeill, Frederick A. Moore, Annette Nilsson, Jane Nunnick, William Osborne, Sean Page, Dhruv Parekh, Catharine Prest, Karen Price, Vivien Price, Mirriam Sangombe, Helen Smith, I Storey, Laura Thrasyvoulou, Kyriaki Tsakiridou, Donna Walsh, Steven Welch, H.A. Willis, Lisa J. Wood, Joanne Woodford, Gemma Wooldridge, Claudia Zullo, Fiona Adam, Krishnan Aniruddhan, J. Gordon Boyd, P. Cochrane, I Fairbairn, Simon Finch, Kimberly Gray, Lauren Hogg, Sophie Iwanikiw, Pan Liu, J Mackenzie, Michael MacMahon, Ian Murray, P. Marks, Andrew Morrow, Jean Penman, Arthur G. Pratt, J. Ramsay, A. Scullion, Helen Sheridan, Marion Simpson, Colin J.R. Stewart, J Tait, Audra Timmins, Margaret Topping, Paul Hine, Paul Albert, Stephen Todd, Ingeborg Welters, Dan Wootton, Muhammad S. Ahmed, Rizwan Ahmed, Amal Al Balushi, Michelle A. Anderson, Abolaji Atomode, Paul Banks, David Barr, John Bassett, Ann Bennett, Hannah Bond, Adrian P. Bracken, T Brankin-Frisby, Giovanna Bretland, Martin B. Brodsky, Jeremy Brown, Claire Burston, J Byrne, Susan A. Casey, Lucy Chambers, David Coey, Tim Cross, James Cruise, John Currie, L Dobbie, Robert J. Downey, An Du Thinh, Gregory Duncan, I Duru, Juliana Early, Kate Fenlon, Imogen Fordham, Helen Frankland, Shannon Glynn, Jack Goodall, Susan Gould, Alvyda Gureviciute, Kathryn Haigh, Mark Hamilton, Lynne Hampson, Anita Hanson, Melanie Harrison, Linda M. Hawker, Phoebe Hazenberg, Stephen Hicks, S Hope, Mark Howard, Karl Hunter, T Ingram, Abdurrahman I. Islim, Francisca Jaime, K Janes, Brian Johnston, Shane Kavanagh, Lynne Keogan, Sarah King, Kestutis Krasauskas, Joseph M. Lewis, M Lofthouse, Paola López, Caroline Lowe, Zahed Mahmood, Katy Martin, Ayren Mediana, Zoe Mellor, P Merron, Benjamin Metcalfe, Maeve Middleton, Katelyn Monsell, Nick Nicholas, Anna Nuttall, Rostam Osanlou, Leigh Pauls, R Price-Eland, Claire Prince, S. Pringle, Eric S. Richardson, Lindsey Rigby, Margaret Foster Riley, Anna Rowe, E Rybka, M Samuel, Dennis P. Scanlon, Joanna Sedano, David Shaw, Farah Shiham, C. Smith, S Stevenson, Alexander Stockdale, Jennifer Tempany, Pinky Thu-Ta, Cheryl Toohey, Ian Turner-Bone, S. Victoria, Alicia Waite, Elizabeth Wasson, Robert Watson, V Waugh, Ruth Westhead, L Wilding, K. Williams, Amanda Wood, Allen Eng Juh Yeoh, Titilope A. Adeyemo, Kate Best, Gavin Bridgwood, Roderic Broadhurst, C. Brockelsby, Tomos Brockley, Jeremy Brown, Ramadan Bujazia, Adrian Burton, Samantha Clarke, Joseph Cremona, Caroline Dixon, S. Dowson, Helena Drogan, Fiona Duncan, M. Emms, Hasan Farooq, David A. Fullerton, Н. Г. Потешкина, Christian Gabriel, S. Hammersley, Richard Hum, Tim Jones, S. Kay, Emma Kelly, Michelle Kidd, David Lees, Richard Lowsby, D Maren, Diego Maseda, Enock Matovu, Karen McIntyre, Hong M. Moulton, Khalid Nourein, Katherine Pagett, Andy Ritchings, Susan M. Smith, Julie Taylor, K.M. Thomas, Killiam Turbitt, Bryan Williams, S Yasmin, Andrew Ang, John Belcher, M Boothroyd, Helen Bowler, Laura Chapman, Kelly Chin, David J. Cohen, Joby Cole, Hayley Colton, Robin Condliffe, M Cribb, Stephen Curran, Thomas C. Darton, Duneesha de Fonseka, Thushan I. de Silva, Angela Dunn, Alison Ellwood, Emma Ferriman, H Foot, Rachel Foster, Zoë Gabriel, Julia Greig, Jennifer L. Hall, Mahboob Ul Haq, S Hardman, Elizabeth Headon, Constance Holden, Kay Housely, Alice Howell, L. Hunt, E Hurditch, F Ilyas, C Jarman, Faith Kibutu, T. Kitching, Samuel Lassa, L Lewis, Ned Lewis, T. J. Locke, H. Luke, A Lye, Luke Mair, G. Margabanthu, Philippa C. May, J McNeill, S Megson, James Meiring, Jonathan Middle, Jennifer T Middleton, Peter E. Morris, Tom Newman, Lauren Passby, Ruth Payne, Megan Plowright, Ajay Raithatha, Gurpreet Rana, Stephen A. Renshaw, Alexander Rothman, David Sammut, Stephen A. Sherwin, Paul J. Simpson, Monique Sterrenburg, Benjamin Stone, Michael Surtees, Alison Telfer, B Thamu, A. A. Roger Thompson, Natalie Vethanayagam, Phillip Wade, Samantha Walker, J G R Watson, Raha West, Tony Williams, Madhura Balasubramaniam, Connor Acton, Sk Akhtar Ahmad, Rizwan Ahmed, A. Ajmi, A. Al-Asadi, S. Altaf, A Amin, Aiysha Bajandouh, Rachel Carey, Z Carrington, Julie Chadwick, S Cocks, C. Dawe, S. Farzana, O Froud, Alex Gibson, Andrew Green, Philip C. Hill, Allyson G. Hindle, Rebecca Holmes, Gareth Hughes, Rebecca C Hull, M. Khalid Ijaz, Richard J K Kalayi, Michael Khan, Aisha Koirata, Stephen R. Latham, George Lipscomb, K. Lipscomb, A McCorkindale, Moira McNulty, O Meakin, Nevan Meghani, Nalin Natarajan, Daniel Nethercott, Patrice K. Nicholas, T Pandya, A. Parkinson, Verma Priyash, L Pugh, Jethin Rafique, James Robertson, Mahmoud Saleh, Wendy Schneblen, Bhawna Sharma, O. P. Sharma, David Shaw, Zak Shehata, Robert Sime, Sally Singh, Richard Smith, Chinari Subudhi, Richard Tallent, E Tanton, K. Teasdale, Daniel Tewkesbury, Phyu Thet, Susan Thornton, John Timerick, C. I. D. Underwood, Na Wang, Matthew Watts, I. Webster, Barnabas Wilson, Catherine Ashbrook-Raby, Avinash Aujayeb, Lisa M. Barton, Jennifer Bell, Stephen C Bourke, Helen Campbell, D. G. Charlton, Kim A. Connelly, D. James Cooper, Amanda Dawson, Lorelle Dismore, Sally Dodds, Catherine Edwards, Simon Fearby, Vernice Ferguson, Andrew R. Green, Nathan Green, Helen Grover, Elizabeth J. Hall, Ibraheem Hamoodi, S. Haney, Peta Heslop, Paul Jones, Holly-May Lewis, Jason J. Luke, C. Logan Mackay, Claire McBrearty, Gerald P. McCafferty, I McEleavy, Hayley McKie, Nicola McLarty, Una McNelis, Andrew Melville, Jonathan Miller, A. Morgan, Sean Parker, L. Patterson, H Peggie, Sara Pick, Hannah Rank, David P Ripley, Sandra Robinson, EJ Rosby, Jeremy Rushmer, Hitesh H. Shah, Timothy F. Smith, Valerie Smith, David Snell, John Steer, E Sykes, Andrew Syndercombe, Christina Tanney, Leanne Taylor, Joseph Ward, Richard Warren, Mark Weatherhead, Rebecca Whittle, Linton Winder, Mohammad Ali, Lori Anderson, A Andrews, Saima Ashraf, David J. Ashton, G Babington, Gillian Bartlett, Dushyant Batra, Linda J. Bendall, Nicola Benetti, Tr Brear, Andreas K. Buck, George Bugg, Joshua Butler, Richard Cammack, Jane Cantliff, Linda Clark, Erin E. Connor, Patrick Davies, M Dent, Cassandra Dobson, Alireza Fatemi, Mostafa Fatemi, Lora E. Fleming, Jane Grundy, Jesper Hallas, Lesley Hodgen, Suzanne Hodgkinson, Shirley Hodgson, Louise M. Howard, Cary T. Hutchinson, Beth Jackson, Jaspreet Kaur, Elizabeth Keddie-Gray, Edward J. Kendall, C. Khurana, Mark Langley, Laura Lawless, Laura Looby, Megan Meredith, Laura Morris, H Navarra, R. Nicol, James D. Oliver, Christina Peters, B. Petrova, Ralph E. Purdy, Zoe Rose, Lucy Ryan, J. Sampson, Garry Squires, J. Squires, Rachel A. Taylor, Alice Thomas, Jim Thornton, Kirsty Topham, Olivier Vincent, Steven Warburton, Stephen P. Wardle, Holly Waterfall, Shilin Wei, T Wildsmith, L. A. Wilson, Rahuldeb Sarkar, Kathy Abernethy, Christopher Adams, Lisa C. Adams, A. Addo, Fine Aliyuda, Simon Archer, A. Arya, E Attubato, Oluwasola Babatunde, Marroan Bachour, P Balasingam, Ashok Bhandari, Felicity Brokke, R.S. Chauhan, Vipal Chawla, Rumbidzai Chineka, Adrienne L. Davis, Nadia Edmond, Mohamed Elbeshy, Charles Ezenduka, S. Ferrón, Chevanthy Gnanalingam, Dzintars Gotham, Michael Hollands, Madiha Iqbal, A. Jamal, Benz Josiah, Shane Kidney, Minhee Kim, K Koukou, Thyra Kyere-Diabour, Laura Leach, Angela Liao, A Maheswaran, M. Mansour, Nahida S Miah, J Morilla, L Naglik, K Naicker, Zubeir Nurgat, N. Shesh, I Redknap, Zia Ur Rehman, Aidan Ryan, Younan Samuel, A. Shaibu, Pavandeep Soor, Ray W. Squires, William J Stagg, Waqar Hassan, Padma Vankayalapati, Eleftheria Vyras, Angharad Williams, Jennifer Wood, Naz Zuhra, Oliver Koch, Ahmad Abu-Arafeh, Emma Allen, Lynsey Bagshaw, Craig Balmforth, Rory Barnes, Ashton Barnett‐Vanes, Rosaleen Baruah, Stephen Begg, Samantha Blackley, M. Braithwaite, Gemma Clark, Sarah Clifford, David H. Dockrell, M. Evans, Victoria Fancois, Caleb Ferguson, Sherry A. Ferguson, N Freeman, Erin Gaughan, E. Godden, S Hainey, Rachel Harrison, Bethany Hastings, Su Htwe, Adriel Ju Wen Kwek, Ke Ming, Owen Lloyd, Chris Mackintosh, Allan MacRaild, Waheed Mahmood, Emily Mahony, Julie S. McCrae, Shaun K. Morris, Carolyn Mutch, S. Nelson, K. Nunn, D. O. Shea, Irvine H. Page, Meghan Perry, Jonathan Rhodes, N. Rodgers, Jenna Schafers, Amanda C. Shepherd, Germander Soothill, Sarah J. Stock, Rebecca Sutherland, Αναστασία Τάσιου, Adnan Tufail, David D. Waters, Rebecca Weerakoon, Tim Wilkinson, Rebecca Woodfield, J Wubetu, M. Krishna Murthy, Rita Arya, Amir Baluwala, Tadhg Blunt, Ricky Chan, Louise Connell, Miriam Davey, Lisa Ditchfield, Gordon B. Drummond, Ahmed Ibrahim, Julian Little, Neil Marriott, B Mathew, May Moonan, Thapas Nagarajan, Soonie R Patel, Helena Prady, Lindsay Roughley, S. Sharma, H Whittle, Geraldine Hamilton, Natalie Blencowe, E Stratton, Miriam Abraham, David H. Adams, Bahar Al-Ramadhani, B Amit, Amena Archer, Gary Asher, G Aziz, Alison Balcombe, Kathryn M. Bateman, Mark Baxter, Lauren Beacham, Kate Beard, Kevin D. Belfield, Nicholas Bell, Michael W. Beresford, Jolanta Bernatoniene, A. Bhat, Deepa Bhojwani, Sarah N. Biggs, C. Blair, Jane Blazeby, Karen Bobruk, Suzanne Brooks, Nicholas M. Brown, Laura Buckley, Peter Butler, Andréa Cannon, C Caws, Ela Chakkarapani, Kevin Chatar, Dereck E. W. Chatterton, Brenda Chivima, Edward G. Clark, Carlota Clemente de la Torre, Kathryn Cobain, Heather Cooke, Donna Cotterill, E. Courtney, Seamus Cowman, Karen Coy, Helen Crosby, Kathryn Curtis, Peter J. Davis, Olivia Drewett, K Druryk, Rosie Duncan, Harvey Dymond, K Edgerley, Mohamed Ekoi, Mohamed Elokl, Ben Evans, Toni Farmery, Natalie Fineman, Adam Finn, Laura D. Gamble, Florence Garty, Ben Gibbison, Lysander Gourbault, David Grant, Katherine E. Gregory, Melanie Griffin, Rachel Groome, Lina Gurung, Virginia Haile, Maryam Hamdollah‐Zadeh, A Hannington, Rachel Harrison, Jonathan Heywood, Andrew Hindmarsh, Nina Holling, C Horrobin, R Houlihan, J Hrycaiczuk, Heather Hudson, Katrina Hurley, Jahangir Iqbal, Richard Jarvis, B Jeffs, Adam Jones, Ruth Jones, Emily King-Oakley, Emily Kirkham, Lynn Kirkpatrick, Rita Kumar, Mohammed Kurdy, Anthony B. Lagnado, Stephen Lang, Lorna Leandro, H. Legge, Fernando Ayuga Loro, Allison Low, Hilary C. Martin, Jean Mayer, Tiffany Mayo, Laura McCullagh, Graham T. McMahon, Louise Millett, Kerry Millington, Ji‐Oh Mok, James Moon, Lauren Morgan, Stephen P. Mulligan, L. Murray, T Nandwani, C. O’Donovan, E. Payne, C Penman, Marius Pezard-Snell, Joe Pickard, M. Pitchford, Charles D. Plumptre, Daniel Putensen, Athimalaipet V Ramanan, José Luis Ramírez, Sarah J. Ratcliffe, Nigel Redman, E. Robbins, Victoria Roberts, Jane Robinson, Marion Roderick, Sean Scattergood, Alvin Schadenberg, Ella Schofield, Rhian Sheppeard, Chiaki Shioi, Jonathan Shurlock, Danny Simpson, Parag Singhal, Agnieszka Skorko, B. Smart, Nicholas Smith, Ray W. Squires, V. Stefania, Colin J.R. Stewart, Matt Stuttard, P. J. Sugden, Sudha Sundar, C Swanson-Low, T. Swart, Edward J. Swift, A Tate, Miriam Thake, K. Thompson, Mary Trevelyan, Kate Turner, S. Turner, A. Tyer, Stefania Vergnano, Robert Vincent, Roger A. Ward, Andrew White, S. Wilkinson, J. Williams, Sophie Williams, Joanna Willis, Helen Winter, Zoe Woodward, Louisa Woollen, Rosalind Wright, A. Younes Ibrahim, James Moon, Rebekah Baldwin-Jones, N. Biswas, Ali Bowes, Heather Button, E Calé, Mandy Carnahan, Emma Crawford, Ellen Damm, Sanjeev Deshpande, Denise Donaldson, Caroline Fenton, Simon Hester, Y. Hussain, Mohammad Ibrahim, Samsul Islam, Jessica Jones, S Jose, Hugh Millward, N Motherwell, Jennifer Nixon, Stanislawa Pajak, Samantha L. Passey, L Price, Megan Rees, Nicholas Rowe, Nicola Schunke, Andrew Stephens, John Stickley, Maria Tadros, Helen Tivenan, Alasdair Gray, James W. Dear, Matthew Adam, Rustam Al‐Shahi Salman, Atul Anand, Richard A. Anderson, J. Kenneth Baillie, David T. Baird, Theodosios Balaskas, James Balfour, Corlane Barclay, Polly Black, C. Blackstock, S Brady, Rachel Buchan, Ryan Campbell, Jonathan Carter, P Chapman, Mark Cherrie, Charis Du Cheyne, Carolyn Chiswick, A. Christides, Daniel Christmas, A.M. Clarke, Michelle Coakley, Alexander Corbishley, A. Coull, Albert Crawford, L Crisp, C. Cruickshank, Dominic Cryans, M Dalton, Kevin Dhaliwal, Maureen Docherty, R Dodds, L. Donald, Stephen Dummer, Michael Eddleston, S. Ferguson, Nicholas Fethers, Edmund Foster, Rebecca Frake, N Freeman, Brian Gallagher, Erin Gaughan, D. Gary Gilliland, E. Godden, Emma Godson, Julia Grahamslaw, Alison Grant, N. Grubb, S Hainey, Zoe Harding, Mark Harris, M Harvey, David Henshall, S. Hobson, Neil Hunter, Yusuf Jaly, J Jameson, D Japp, Htet Htet Ei Khin, Laura Kitto, Sean Krupej, Charles Langoya, Rex Lawrie, A Levynska, M. Patrice Lindsay, Adam Lloyd, Shiong Wen Low, Barrie Lyell, Daniel Lynch, John K. MacFarlane, Lisa MacInnes, I. MacIntyre, Allan MacRaild, Maria Marecka, Adam Marshall, María Martin, Emily McBride, Conor McCann, Fiona McCurrach, Mary McLeish, Ross Medine, Hazel Milligan, Emma Moatt, Wendy Morley, S. Morrison, Mary Morrissey, Kenneth Murray, S. Nelson, David E. Newby, Khwaja Nizam Ud Din, Rebecca F. O’Brien, Miranda Odam, Eoin O’Sullivan, R Penman, A. Townsend Peterson, Paul J. Phelan, Gillian Pickering, Tom Quinn, Nichola Robertson, L. W. Rooney, Neil J. Rowan, Megan Rowley, Rustam Al‐Shahi Salman, Anne Saunderson, Jenna Schafers, Catherine A. Scott, Lisa K. Sharp, Amanda C. Shepherd, Jennifer Simpson, Eric J. Small, P. Stefanowska, Andrew Stevenson, Sarah J. Stock, John Teasdale, E. Thompson, Jacqui Thompson, Ian D. Walker, Kim Walker, Angharad Williams, Nathan D. Wong, Judith Abrams, A Alkhudhayri, N. Aung, Alexander J. Baldwin, Oliver Bannister, Joseph Barker, Heidi Beddall, Helen Blamey, Evelyn Chan, Josephine Chaplin, Ben Chisnall, Christopher J. Cleaver, Marta Martin Corredera, Shane Crotty, Helen Cui, Bethan Davies, Pradip Dey, Louise Downs, Siobhan Gettings, Beatrice Hammans, Sarah R. Jackman, Paul Jenkins, Mervi Könönen, Søren Kudsk‐Iversen, Aurimas Kudzinskas, Myra Laurenson, Rosa Mancinelli, Jessica A. Mandeville, Katarina Manso, Brynn E. Marks, Sally McLure, O Michalec, Emily Morgan-Smith, Alice Ngumo, H. Norman Noe, Ruth Oxlade, Akash D. Parekh, Vivek Pradhan, Muhammad Aziz Rahman, Chris Robertson, Roberto Rule, S. Shah, Helen Smith, Julie Tebbutt, Nicola Vella, Mihály Veres, Alastair Watson, Raha West, Luke M. Western, Marion Zammit-Mangion, Mohammad I. Zia, Graham Cooke, Louise Young, O. S. Adedeji, Emmanuel O Adewunmi, Z Al-Saadi, R Ashworth, James Barnacle, Niamh Bohnacker, Adam P. Cann, Fanjun Cheng, James Clark, S. Cooray, S Darnell, Anna Daunt, Vivek Pravin Dave, A. D’Mello, Lynsey Evison, Sonia Fernandez Lopez, Felicity Fitzgerald, Chris P Gale, Malick M. Gibani, Sandra J. Hamilton, Stephanie Hunter, Ana Jiménez Gil, Simreen Kaur Johal, Bryony Jones, Athanasia Kountourgioti, Julius Labao, Vaughan M. Latham, Norman Madeja, Sheila Mashate, C.A. Matthews, Helen McLachlan, A Mehar, Jeremy Millard, María Molina, A. Perry, Sara Rey, Stephen Ryder, Rashmee U. Shah, Robert J. Thomas, David Thornton, J. Tuff, Elizabeth Whittaker, C Wignall, Peter Wilding, CL Wong, Thomas Yates, Chang Yu, Tabitha Mahungu, Hasan Tahir, A Abdul, Rezan A. Kadir, Heba Aboelela, M. Al-Khalil, N. C. Allan, Inji Alshaer, Michelle A. Anderson, Maria das Graças Rodrigues de Araújo, GR Badhan, Ameet Bakhai, Sanjay Bhagani, Boniface Bobie, Alba Brraka, Ben Caplin, Aaron E. Carroll, Hannah Century, Elaine Cheung, David J. Cohen, Olutoyin Coker, David Collier, Victor Conteh, Nichola Cooper, Jacolene Crause, Neil M Davies, Ruth Davies, Vashist Deelchand, Maryam Dosani, Loveth Ehiorobo, Chiara Ellis, Gloria Ferenando, Jessica M. Franklin, Paula Gardiner, F Geele, Jivendra Gosai, NK Handzewniak, E Hanison, S Hanson, Niels Holdhof, Heather Hughes, Clifford R. Jack, Casey A. Jarvis, V. Jennings, Hyeon‐Kyoung Koo, V. Krishnamurthy, Amit Kurani, Z. Ladan, Leslie R. Lamb, Anthony E. Lang, Lê Văn Duyệt, Stephen Lee, Stephanie W. Lo, Akish Luintel, A. Maharajh, Haider Mahdi, Toluwani Majekdunmi, Darwin Matila, S. Melander, Francesca Mellor, Aoife Molloy, Russell R. Moores, José María López Morales, Gökhan Moray, Aarti Nandani, Sophia Nasa, S O'Farrell, Amin Oomatia, Anna Osadcow, Jennifer Osei-Bobie, Glykeria Pakou, Prashant Patel, Caroline Patterson, Eleanor Pyart, Joo Wei Ethan Quek, Simon Rabinowicz, Tommy Rampling, Rajesh Rankhelawon, Alison Rodger, Antonia Scobie, S. Sharma, Claire Singh, Sarah Sithiravel, Toluleyi Sobande, Peter S. Talbot, Priyal Taribagil, Sachuda Veerasamy, George Wallis, Jennifer Whiteley, Eric Witele, Adriana Méndez Wong, Edward Woodford, Naveed Yaqoob, K. McCullough, H A Abu, Christy Beazley, H. Blackman, Paul Bradley, D Burda, Ben Creagh‐Brown, John De Vos, Sheila Donlon, Caroline Everden, Jennifer O. Fisher, Henry H. Gale, D. A. Greene, Ozan Hanci, Lois M. Harden, Elizabeth Harrod, Nathan Jeffreys, Emily Jones, Jessica Jones, Rebecca Jordache, C Marriott, Irving Mayanagao, Reena Mehra, Natalia Michalak, Omar Mohamed, Sheila Mtuwa, Krishma Odedra, Christopher Piercy, Veronika Pristopan, Anne Salberg, M Sanju, Eleanor Smith, Sarah Stone, Esther Tarr, Jerik Verula, Mark Ainsworth, Clare Arnison-Newgass, A. Bashyal, K Beadon, Sally Beer, Angela Bloss, Linda B. Buck, Daniel Buttress, William J. Byrne, Anne Capp, Paul Carter, Lucy Carty, Paola Cicconi, R. Corrigan, Charlie Coston, Laura Cowen, Natalie Davidson, Kathryn Dixon, Louise Downs, John Edwards, Rachael A Evans, Siobhan Gardiner, Demetrios Georgiou, Annelies Gillesen, A Harin, May Havinden-Williams, Clare Hird, Andrew Hudak, Paula Hutton, Robert Irons, Patrycja Jastrzebska, Sarah Johnston, Musaiwale M Kamfose, Keir Lewis, T. Lockett, F Maria del Rocio, Jemer Garrido, S. Masih, Alexander J. Mentzer, Shaun K. Morris, Ginny Mounce, Christopher O’Callaghan, Zoe Oliver, J Patachako, Stéphane Paulus, Edith A. Perez, Latha Periyasamy, David A. Porter, Sriram Prasath, Corrina Purdue, Maheshi Ramasamy, Charles Christoph Roehr, А. П. Руденко, Verónica Sánchez, Avishay Sarfatti, Manuel Segovia, Teswaree Sewdin, John F. Seymour, Vicki Skinner, Lauren C. Smith, Alberto Sobrino Diaz, Gaurav Soni, Michelle Taylor-Siddons, Hannah Thraves, Chi‐Ching Tsang, Manu Vatish, Y. Warren, Eve Wilcock, Tabitha Wishlade, Gabriele Boehmer, Ana Alegria, Ritoo Kapoor, Neil Richardson, Korede K. Adegoke, Louise Allen, Satya D Anantapatnaikuni, Daniel Baker, Eva Beranová, Hayley Blackgrove, T Boumrah, Peter Christian, Tracey Cosier, Nikki Crisp, Thomas A. Curtis, Joshua S. Davis, J Deery, Amira M. El Gohary, Tarek Elsefi, Andrew Gillian, C. Hargreaves, T Hazelton, G Hector, Richard C. Hulbert, Axinte Ioniţă, Andrew T. Knight, C. Arenas Linares, Simin Liu, David Loader, Kunal A. Lodhia, Sema Mandal, Elina Matisa, Joseph McAndrew, Kim Mears, Scott J. Millington, May E. Montasser, Andrew M. Moon, Clements Oboh, Pamela Offord, S. Parashar, Manish Patel, Carolyn Pelham, Christopher Price, J Quindoyos, Aylur Rajasri, Jacob H. Rand, S. Rogers, S Saminathan, Nina Schumacher, A.M. Skaria, Reanne Solly, D. Starnes, David Stephensen, Sarah Stirrup, Lauren Tague, Sorrell Tilbey, Sharon Turney, Vimal Vasu, A Velugupati, Mario Venditti, Rachel Vernall, H Weston, Zoe Woodward, Ray Sheridan, Matthew Masoli, Hugh Bakere, A Bowring, TG Burden, Alison Corr, Patrycja Czylok, Lee Dobson, Alan Forrest, Elizabeth Goodwin, Hannah Gower, Anthony Hall, Sadie Heddon, George Joseph, Lynn M. Knowles, Hannah Mabb, Ami Mackey, V. Mariano, E Matkins, Ellen McEvoy, Laura Mckie, Philip Mitchelmore, Lucy Morgan, Tom E. Nightingale, Richard A. Oram, Clare Oreilly, Neville N. Osborne, H Palfrey, Scott B. Patten, Jonathan Pearce, Isabella Seaton, A Smallridge, Peter K. Smith, Matthew Steward, Dominic L. Sykes, Jennifer L. Tipper, Stephen Todd, C. Renee Webb, Simon Whiteley, Simon Wilkins, Nicholas Withers, Kamarul Zaki, Lily Zitter, Ewan Hunter, Rachel Agbeko, Adam L. Bailey, Kenneth F. Baker, Andrew Barr, E W Cameron, Quentin Campbell Hewson, Anthony De Soyza, C.J. Duncan, Marieke Emonts, A Fenn, Sarah Francis, Jan Glover Bengtsson, A Greenhalgh, Aidan T. Hanrath, Helen Hanson, Constantin Hays, K. Houghton, Dean R. Jerry, Graeme Jones, Sadie Kelly, Alan Kimber, Nicholas D. Lane, John K. MacFarlane, Paul McAlinden, I McCullagh, Stuart A.C. McDonald, Omair Mohammed, P. Nwajiugo, R. Obukofe, Rachael Parke, A. Patience, Brendan Payne, Richard Percival, David Price, Zarine Razvi, Nigel Rice, Steve Robson, A. Sanchez-Gonzaléz, Benjamin Shillitoe, Andrew Stanton, E. J. Stephenson, Nicola A Trewick, Sharon Tucker, R. F. Welton, S West, Emma Williams, Eric Wong, F. Yelnoorkar, Jackie Raw, R. Tully, Kula Abdusamad, Zhelyazkova Antonina, Erol Ayaz, Bethan Blackledge, Paul Bradley, Freddie Bray, Michael G. Bruce, E. Bullock, Claire Carty, B. G. Charles, Gavin Connolly, Claire C. Corbett, Jocelyn Cornwell, Sarah M. Dermody, Laura Jayne Durrans, Uchenna Elenwa, Ester Falconer, Jan Flaherty, Julie Fox, Jean‐Luc Guérin, Daniel Hadfield, John Harris, James Haslam, Spencer Phillips Hey, Lee Hoggett, Alex Horsley, Catherine Houghton, L Howard-Sandy, S. Hussain, Richard Irving, P. Jacob, D Johnstone, R. Joseph, Prakash Kamath, Taslima Khatun, Thomas Lamb, Hkw Law, M. Lazo, Gabriella Lindergard, Siddharth Lokanathan, Laura Macfarlane, Stephy Mathen, S McCullough, Paddy McMaster, Denise McSorland, Jane Melville, Brahmeshwar Mishra, G Moth, Michael Mulcahy, Simon Munt, Jay Naisbitt, A Neal, Roger Newport, George O'connor, Deirdre O’Riordan, Irvine H. Page, Vinay Parambil, Jennifer Philbin, MT Pinjala, Chloe Rishton, Michael Riste, Jonathan Rothwell, Maria Sam, Zainab Sarwar, Lyndsay Scarratt, Amit Sengupta, H. Sharaf, Jane Shaw, Kate Shepherd, Andrew Slack, D. N K Symon, Helen T-Michael, Andrew Ustianowski, Otis R. Walton, Sarah Warran, Sophie Williams, Matthew Frise, R. Arimoto, Joy Armistead, Ayesha Aslam, Andrew C. Barrett, S. Bartley, K Bostock, Alison Burman, C Fielder Camm, Richard T. Carson, Holly Coles, J. D’Costa, A. M. Donohoe, Emma Duffield, François Émond, Serenydd Everden, Elizabeth Gabbitas, Emma-James Garden, N Gould, Sabi Gurung, Stephen J. Hadfield, Azzah Muhammad Hayat, Sarah Haysom, James Hilton, Nicholas A. Jacques, Liza Keating, Charles H. Knowles, Hannah Lawrence, K Lennon, B. Mitchell, T C Okeke, N. Shesh, L. Sathyanarayanan, Faye Selby, M Thakker, S Vettikumaran, Andrew Walden, Peter Horby, Leon Peto, Natalie Staplin, Mark Campbell, Guilherme Pessoa-Amorim, Marion Mafham, Jonathan Emberson, Richard Stewart, Benjamin Prudon, Alison Uriel, Christopher Green, Devesh Dhasmana, Flora Malein, Jaydip Majumdar, Paul Collini, Jack Shurmer, Bryan Yates, J. Kenneth Baillie, Maya H Buch, Jeremy Day, Saul N. Faust, Thomas Jaki, Katie Jeffery, Edmund Juszczak, Marian Knight, Wei Shen Lim, Alan Montgomery, Andrew Mumford, Kathy Rowan, Guy Thwaites, Richard Haynes, Martin Landray - Nature Communications 2024 被引用: 9

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome.