Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors

著者: Meijia Yang, Xin Tang, Zongliang Zhang, Lei Gu, Wei Heng, Shasha Zhao, Kunhong Zhong, Min Mu, Cheng Huang, Caiying Jiang, Jianguo Xu, Gang Guo, Liangxue Zhou, Aiping Tong - Theranostics 2020 被引用: 185

Purpose: Given that heterogeneous expression and variants of antigens on solid tumors are responsible for relapse after chimeric antigen receptor (CAR)-T cell therapy, we hypothesized that combinatorial targeting two tumor-associated antigens would lessen this problem and enhance the antitumor activity of T cells.