A Two-Layered Targeting Mechanism Underlies Nuclear RNA Sorting by the Human Exosome

著者: Guifen Wu, Manfred Schmid, Leonor Rib, Patrik Polák, Nicola Meola, Albin Sandelin, Torben Heick Jensen - Cell Reports 2020 被引用: 75

3' ends defined by canonical pA site use. Irrespective of this clear division, NEXT and PAXT act redundantly in two ways: (1) regional redundancy, where the majority of exosome-targeted transcription units produce NEXT- and PAXT-sensitive RNA isoforms, and (2) isoform redundancy, where the PAXT connection ensures fail-safe decay of post-transcriptionally polyadenylated NEXT targets. In conjunction, this provides a two-layered targeting mechanism for efficient nuclear sorting of the human transcriptome.