Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines

著者: Long Chen, Hao Qin, Ruifang Zhao, Xiao Zhao, Liangru Lin, Yang Chen, Yixuan Lin, Yao Li, Yuting Qin, Yiye Li, Shaoli Liu, Keman Cheng, Hanqing Chen, Jian Shi, Gregory J. Anderson, Yan Wu, Yuliang Zhao, Guangjun Nie - Science Translational Medicine 2021 被引用: 233

T and NK cells were crucial to the vaccine-elicited tumor regression. Individualized autologous tumor antigen vaccines based on effective activation of the innate immune system by bacterial cytoplasmic membranes hold great potential for personalized treatment of postoperative patients with cancer.