Intestinal commensal microbiota and cytokines regulate Fut2 + Paneth cells for gut defense

著者: Mariko Kamioka, Yoshiyuki Goto, Kiminori Nakamura, Yuki Yokoi, Rina Sugimoto, Shuya Ohira, Yosuke Kurashima, Shingo Umemoto, Shintaro Sato, Jun Kunisawa, Yu Takahashi, Steven E. Domino, Jean-Christophe Renauld, Susumu Nakae, Yoichiro Iwakura, Peter B. Ernst, Tokiyoshi Ayabe, Hiroshi Kiyono - Proceedings of the National Academy of Sciences, PNAS 2022 被引用: 58

Significance Paneth cells produce granules containing antimicrobial peptides, such as α-defensin for host defense. Examination of the production and utilization of fucosyltransferase 2 (Fut2) by Paneth cells revealed two distinct subsets: Fut2 + Paneth cells and Fut2 − Paneth cells. Compared with Fut2 − Paneth cells, Fut2 + Paneth cells were enriched in granules containing antimicrobial peptides. IL-22 and IL-17a were found to be essential for commensal bacteria-dependent Fut2 + Paneth cell development and function as part of gut defense.